interleukin-10


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in·ter·leu·kin-10

(in'tĕr-lū'kin),
A cytokine derived from helper T-cell lymphocytes (Th2) that inhibits γ-interferon (IFNγ) and IL-2 secretion by T-cell lymphocytes (Th1) and inhibits mononuclear cell inflammation.

interleukin-10 (IL-10)

a protein expressed by CD4 and CD8 T cells, monocytes, macrophages, and activated B cells. It inhibits cytokine synthesis and suppresses the functions of macrophages and natural killer T cells.

IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

in·ter·leu·kin-10

(in'tĕr-lū'kin)
A cytokine derived from helper T-cell lymphocytes, B-cell lymphocytes, and monocytes that inhibits interferon gamma; (IFNγ) secretion by T-cell lymphocytes and it inhibits mononuclear cell inflammation.

interleukin-10

A CYTOKINE produced by helper T cells, B cells, MACROPHAGES, and the placenta that inhibits gamma-interferon secretion and mononuclear cell inflammation.
References in periodicals archive ?
Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population.
Amniotic fluid interleukin-10 (IL-10) concentrations during pregnancy and with labor.
Citation: "mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation"; O.
Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis.
Lack of Association of genetic polymorphisms in the interleukin-1 p, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese.
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression.
Objective: We assessed the association between interleukin-10 (IL-10) -1082G/A and -592C/A polymorphisms, and coronary heart disease (CHD).
Interleukin-10 levels are often elevated in serum of adults with Hodgkin's disease and are associated with inferior failure-free survival.
Elevated serum levels of interleukin-10 and IFN-gamma in patients with acute Plasmodium falciparum malaria.
Statistical analyses were used to create a biomarker risk score, which included levels of a number of protein biomarkers, including fibrinogen (a clotting protein), interleukin-10 (associated with the immune system) and C-reactive protein (an inflammatory marker).
Next, they measured mitogen-activated protein kinase phosphatase-1 (MKP-1) and interleukin-10 (IL-10).