IL23A

(redirected from interleukin 23, alpha subunit p19)

IL23A

A gene on chromosome 12q13.13 that encodes interleukin-23A, a cytokine which associates with IL-12B to form IL-23, a heterodimeric cytokine involved in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the JAK-START signalling cascade, stimulates memory T cells and promotes production of proinflammatory cytokines.
 
Molecular pathology
IL-23 may induce autoimmune inflammation and play a role in tumourigenesis.
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