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interim analysis

   Also found in: Wikipedia 0.01 sec.
interim analysis
Clinical trials Analysis of early data accumulated in a clinical trial, before all of the Pts have been enrolled, to detect trends that might warrant modification of the protocol, change in type or format of data being collected or, if extreme, trial termination. See CONSENSUS II.


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At the mid-point of the trial, a planned interim analysis reviewed full data for 340 patients.
The study was stopped early on the recommendation of an independent data safety monitoring board after a preplanned interim analysis showed that combining Tarceva with Avastin significantly extended the time that patients lived without their disease advancing, as defined by PFS (progression-free survival), compared with Avastin plus a placebo.
The company said the decision was made after the trial's final scheduled interim analysis showed that one of the two Prochymal dose arms had crossed a futility boundary.
 
 
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