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interferon-alpha |
Also found in: Acronyms, Encyclopedia, Wikipedia, Hutchinson | 0.02 sec. |
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interferon-alpha, the major interferon produced by virus-induced leukocyte cultures. The primary producer cells are null lymphocytes, and the major activities are antiviral activity and activation of natural killer cells. It is used in the experimental treatment of hairy cell leukemia and other selected neoplasias. Also spelled interferon-alfa. interferon-alpha IFN-α Immunology A family of 20 leukocyte-derived immunomodulating glycoproteins with antiproliferative and antiviral activity Indications Recombinant IFN-α is used to treat hairy cell leukemia, CML, KS,
HPV-related proliferations–eg, condyloma acuminatum, respiratory papillomatosis, pulmonary hemangioendotheliosis, chronic hepatitis–eg, HCV, as well as renal CA ±vinblastine, NHL, and to inhibit angiogenesis Side effects Flu-like
Sx, malaise, fatigue, headache, anxiety, vertigo, depression, ↑ aminotransferase, BM suppression–granulocyte toxicity, SVT with hypotension or HTN, potentially fatal CHF, exacerbation of multiple sclerosis;1⁄2
of Pts, especially with cirrhosis and hypersplenism don't tolerate therapy because of fatigue, profound thrombocytopenia and neutropenia. See Angiogenesis inhibitors. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The in vivo and in vitro effects of chicken interferon-alpha on infectious bursal disease virus and Newcastle disease infection. In preclinical studies, celgosivir has demonstrated strong synergy with interferon-alpha with and without Interferon-alpha in mixed cryoglobulinemia patients: randomized, crossover-controlled trial. |
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