integrins


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in·te·grins

(in-te'grinz),
A family of cell membrane glycoproteins that are heterodimers composed of α- and β-chain subunits. They serve as extracellular matrix glycoprotein receptors involved in cell adhesion, for example, the mediation of adhesion of neutrophils to endothelial cells.
[L. integer, whole, intact, fr. in- + tango, to touch + -in]

integrins

A familty of linked polypeptide chains, alpha and beta, that mediate adhesions and other interactions between cells and the extracellular matrix and between cells and other cells. Integrins are expressed on endothelial cells, leukocytes, other cells and platelets, and act as receptors for fibrinogen, fibronectin, thrombospondin, von Willebrand factor, and vitronectin. See also DISINTEGRINS.

integrins (inˑ·t·grinz),

n.pl. proteins that mediate interactions be-tween two cells as well as between a cell and the extracellular matrix.

integrins

a group of receptors that promote cell adhesion.
References in periodicals archive ?
A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by beta1 and beta2 integrins.
Unfortunately, integrins also help cancer cells that have broken away from a cancerous tumour to take root elsewhere in the body.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter R Integrins.
The established method of preparing an MRI molecular probe of RGD ligand for metastasis-associated factor integrin a[sub]v[sz][sub]3 is as follows: first, DGL-PEG was synthesized.
0mM resulted in stratification as well as differentiation and stratification is generally held to involve the reduction in the affinity of the extracellular matrix receptors, the integrin for their ligands, which include FN.
Its portfolio of integrin antagonists has potential utility in a broad range of fibrotic diseases.
Furthermore, when they artificially activated integrin in mice with aged muscles, their regenerative abilities were restored to youthful levels.
Integrins are dimeric extracellular matrix receptors composed of one a and one [beta] subunit (for review see Campbell and Humphries, 2011).
In addition, an upregulation of [alpha]5[beta]1 integrins has been found in malignant breast cancer cells.
Integrins cause strong adhesion between the endothelium and its ligands.