integrin


Also found in: Dictionary, Encyclopedia, Wikipedia.

integrin

/in·te·grin/ (in´tĕ-grin) any of a family of heterodimeric cell adhesion receptors, each consisting of an α and a β polypetide chain, that mediate cell-to-cell and cell-to–extracellular matrix interactions.

integrin

(ĭn′tə-grĭn)
n.
Any of a group of transmembrane proteins that bind to certain molecules in the extracellular matrix or on the surface of other cells. They are involved in cell adhesion and motility and in the transmission of signals across the plasma membrane.

integrin

[integ′rin]
1 a protein that links the outside of a cell with its interior.
2 a heterodimeric molecule involved in cell-substate and cell-cell adhesion.

integrin

a receptor PROTEIN allowing cells to bind to and respond to the EXTRACELLULAR MATRIX. Integrins are members of a large family of cell adhesion receptors involved in cell-extracellular matrix and cell-cell interactions. see ANOIKIS.
References in periodicals archive ?
LAD-I is caused by mutations in the ITGB2 gene coding b2 subunit of beta 2 integrin family.
The established method of preparing an MRI molecular probe of RGD ligand for metastasis-associated factor integrin a[sub]v[sz][sub]3 is as follows: first, DGL-PEG was synthesized.
Identification of a novel calcium-binding protein that interacts with the integrin alpha (IIb) cytoplasmic domain.
His results have demonstrated that fundamental quantum forces are work to explain the way the integrin protein was behaving in the experiments.
Integrin stabilizes muscle structure, and helps stimulate muscle repair and regeneration, Burkin said.
Joseph M and Watt F M, worked on keratinocytes :stem cells and cells which undergo terminal differentiation and found out that b1 integrin expression helps in distinguishing stem cells from those undergoing terminal differentiation in vivo and in vitro.
Its portfolio of integrin antagonists has potential utility in a broad range of fibrotic diseases.
Other classes of molecules involved in pathogenesis of retinal new vessels other than growth factors include integrin are which act as specific extracellular matrix proteins.
Integrins are proteins that 'integrate' the outside to the inside of the cell, providing a connection to the immediate external environment, and without them, almost every stage of the regenerative process is disrupted.
The Role of uPAR Signaling and Integrin Activation in Podocytes and Proteinuric Kidney Diseases
The antibodies that we used in this study were as follows: p63 antibody (#sc-8431, Santa Cruz Biotechnology, Santa Cruz, CA), proliferating cell nuclear antigen antibody (PCNA, #M0879, DAKO, Glostrup, Denmark), integrin [alpha]6 antibody (#sc-6597, Santa Cruz Biotechnology), integrin [beta]1 antibody (#sc-9970, Santa Cruz Biotechnology), and type IV collagen antibody (239M-16, Cell Marque, Rocklin, CA).
Based on samples from 160 patients that included benign nevi and primary skin melanomas with and without SLN metastasis, investigators identified genes differentially expressed between metastatic and nonmetastatic pigmented skin lesions, and found a cluster of genes associated with integrin cell adhesion.