integrin


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integrin

/in·te·grin/ (in´tĕ-grin) any of a family of heterodimeric cell adhesion receptors, each consisting of an α and a β polypetide chain, that mediate cell-to-cell and cell-to–extracellular matrix interactions.

integrin

(ĭn′tə-grĭn)
n.
Any of a group of transmembrane proteins that bind to certain molecules in the extracellular matrix or on the surface of other cells. They are involved in cell adhesion and motility and in the transmission of signals across the plasma membrane.

integrin

[integ′rin]
1 a protein that links the outside of a cell with its interior.
2 a heterodimeric molecule involved in cell-substate and cell-cell adhesion.

integrin

a receptor PROTEIN allowing cells to bind to and respond to the EXTRACELLULAR MATRIX. Integrins are members of a large family of cell adhesion receptors involved in cell-extracellular matrix and cell-cell interactions. see ANOIKIS.
References in periodicals archive ?
Andrei Yudin of the University of Toronto in partnership with MaRS Innovation, is developing its lead orally-bioavailable macrocycle drug to target integrin a[sub.
Du and his colleagues found that the G protein G-alpha-13 binds to the inner side of the integrin molecule when the outside portion binds to the matrix.
The Alpha6 Beta4 Integrin signaling pathway activates the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules.
The company is currently pursuing the preclinical development of an alpha-4-beta-7 integrin specific oral peptide antagonist and preclinical discovery of oral IL23 receptor antagonists as new chemical entities (NCEs) for treatment of IBD.
According to Matunis, the increase in integrin allows somatic stem cells to gain the upper hand because they can stick to the niche better than neighboring germline stem cells can.
The poster presentation, entitled "A Phase I Study of IMGN388, an Antibody Drug Conjugate Targeting v Integrin, in Patients with Solid Tumors," reports findings from the trial's dose-finding phase, which was designed to determine the maximum tolerated dose of the compound when administered once every three weeks.
He says that the latest set of findings suggest that integrin helps the anchor cell orient itself toward the basement membranes, and that it also directs netrin to build the puncta in the proper place to ease an opening through.
a biotechnology company focused on innovative therapies for fibrosis and organ failure, announced today that it has exclusively licensed the rights to a monoclonal antibody to integrin v5 from the University of California.
The Finnish Funding Agency for Technology and Innovation (Tekes) has, based on an application from Biotie, informed the Company that it has decided to forgive certain capital loans relating to Biotie's carbohydrate and cancer glycosylation projects that were discontinued in 2005 and an R&D loan relating to Biotie's Integrin project that was discontinued in 2010.
Boffins believe that the key to this is a protein on the surface of cancer cells called integrin that allows them to stick to the vessels, PLoS ONE journal reports.
A Phase I Study of IMGN388, an antibody drug conjugate targeting av Integrin, in patients with solid tumors" (Abstract #472, Poster board #008).
About Entyvio(TM) (vedolizumab) Entyvio, an integrin receptor antagonist, is a humanized monoclonal antibody that specifically binds to the alpha4beta7 integrin and blocks the interaction of alpha4beta7 integrin with mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and inhibits the migration of memory T-lymphocytes across the endothelium into inflamed gastrointestinal parenchymal tissue.