The chicoric acid appears to disturb this process of HIV integration by halting function of the HIV integrase
, thus preventing HIV from reproducing and infecting other cells, they said.
The findings also reveal that, of the emerging therapies, ViiV's integrase
inhibitor dolutegravir is best poised for commercial success during the 2011-2021 forecast period.
Triumeq is a once-daily dolutegravir-based regimen, containing the integrase
strand transfer inhibitor (INSTI) dolutegravir and the nucleoside reverse transcriptase inhibitors (NRTIs) abacavir and lamivudine.
inhibitors, the latest weapon in the HIV treatment armamentarium, stop HIV from incorporating its genetic information into the DNA of an infected T cell, essentially heading off HIV's master plan to hijack all future generations of cells.
As well as viral cDNA, this complex contains viral matrix (MA), viral protein R (Vpr), reverse transcriptase (RT), integrase
and several cellular proteins.
Strains were screened for the integrons by polymerase chain reaction by using three sets of primers specific for the intI1, intI2, and intI3 genes coding for the integrase
as described previously (3).
Some of the targets that might be important include structural elements (such as the highly conserved zinc finger motif of the HIV nucleocapsid or the viral enzymes integrase
and RNase H), regulatory and accessory proteins, processes (such as transcription, nuclear import and export of viral nucleic acid, and macromolecular interactions), and host targets (adhesion molecules, transcription factors, apoptosis, and signaling pathways).
Although the researchers so far have confined their experiments to cells in laboratory dishes, the compounds are the first to clearly render integrase
incapable of splicing viral DNA onto host-cell DNA.
The Quad combines Truvada with Elvitegravir (an integrase
inhibitor similar to Merck's Isentress) and Cobicistat (a blood booster similar to the decade-old Norvir).
Both FIV and HIV rely on a protein called integrase
that inserts the virus' DNA into an infected cell's DNA.
ViiV Healthcare today launches its first new treatment, the integrase
inhibitor, dolutegravir (TIVICAY[sup.
Tivicay is an integrase
strand transfer inhibitor that interferes with one of the enzymes necessary for HIV to multiply.