Currently dolutegravir (DTG) in combination with either abacavir (ABC) or rilpivirine (RPV) and the investigational integrase
inhibitor cabotegravir (CAB) in combination with RPV are being studied in 2-drug regimens.
To better identify who should be screened for INSTI resistance at ILH, a retrospective review on all patients who underwent PhenoSense Integrase
testing (Monogram Bioscience) between January 1, 2012 and June 30, 2013 was performed.
IntI1F###ACGAGCGCAAGGTTTCGGT###Class 1 integrase
The deal is in line with Shionogi's and ViiV Healthcare's aim to optimise the advancement of the integrase
inhibitor portfolio, the companies said.
2+] sobre a interacao entre o acido 3,5-dicafeoilquinico e a integrase
About one third of HIV-positive people studied at Albany Medical Center had an important drug-drug interaction involving one of the medications in a first antiretroviral combination that included a protease inhibitor (PI), a nonnucleoside (NNRTI), or the integrase
inhibitor Isentress (raltegravir).
Toward that goal, they developed peptides (called "mix") that can penetrate into infected cells and stimulate the activity of the viral integrase
The new drug, which industry analysts believe could reach the market in 2013, belongs to a class of AIDS drugs known as integrase
inhibitors, designed to block genetic information needed for the human immunodeficiency virus (HIV) to reproduce.
In a second paper recently published in the Journal of Molecular Biology, the Scripps team has used computational modeling to improve understanding of another HIV enzyme and key drug target - integrase
When HIV infects someone, it uses integrase
to paste a copy of its genetic information into their DNA.
The scientists said that having the integrase
structure means researchers can begin fully to understand how integrase
inhibitor drugs work, how they might be improved, and how to stop HIV developing resistance to them.
researchers said they had grown a crystal that enabled them to see the structure of an enzyme called integrase
, which is found in retroviruses like HIV and is a target for some of the newest HIV medicines.