integrase


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integrase

(ĭn′tĕ-grās)
A retroviral enzyme that incorporates DNA derived from the virus into host cell chromosomes. The enzyme is a target for experimental antiretroviral therapies.

integrase

an enzyme involved in the integration of some viruses, such as bacteriophage lambda, and some transposons into host cell chromosomal DNA.
References in periodicals archive ?
Currently dolutegravir (DTG) in combination with either abacavir (ABC) or rilpivirine (RPV) and the investigational integrase inhibitor cabotegravir (CAB) in combination with RPV are being studied in 2-drug regimens.
To better identify who should be screened for INSTI resistance at ILH, a retrospective review on all patients who underwent PhenoSense Integrase testing (Monogram Bioscience) between January 1, 2012 and June 30, 2013 was performed.
The deal is in line with Shionogi's and ViiV Healthcare's aim to optimise the advancement of the integrase inhibitor portfolio, the companies said.
2+] sobre a interacao entre o acido 3,5-dicafeoilquinico e a integrase do HTLV-I.
About one third of HIV-positive people studied at Albany Medical Center had an important drug-drug interaction involving one of the medications in a first antiretroviral combination that included a protease inhibitor (PI), a nonnucleoside (NNRTI), or the integrase inhibitor Isentress (raltegravir).
Toward that goal, they developed peptides (called "mix") that can penetrate into infected cells and stimulate the activity of the viral integrase.
The new drug, which industry analysts believe could reach the market in 2013, belongs to a class of AIDS drugs known as integrase inhibitors, designed to block genetic information needed for the human immunodeficiency virus (HIV) to reproduce.
In a second paper recently published in the Journal of Molecular Biology, the Scripps team has used computational modeling to improve understanding of another HIV enzyme and key drug target - integrase.
When HIV infects someone, it uses integrase to paste a copy of its genetic information into their DNA.
The scientists said that having the integrase structure means researchers can begin fully to understand how integrase inhibitor drugs work, how they might be improved, and how to stop HIV developing resistance to them.
researchers said they had grown a crystal that enabled them to see the structure of an enzyme called integrase, which is found in retroviruses like HIV and is a target for some of the newest HIV medicines.