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insulitis

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insulitis /in·su·li·tis/ (in″sdbobr-li´tis) lymphocytic infiltration of the islets of Langerhans, suggesting an inflammatory or immunologic reaction.
in·su·li·tis (ns-lts)
n.
A histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells.

insulitis
[in′səlī′tis]
a lymphocytic infiltration of the pancreatic beta cells in the islets of Langerhans. The condition is associated with the development of type 1 diabetes mellitus. Also called isletitis.

insulitis [in″su-li´tis]
cellular infiltration of the islets of langerhans, a reaction similar to that observed in autoimmune diseases.

insulitis
cellular infiltration of the islets of Langerhans, possibly in response to invasion by an infectious agent.


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Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice.
But Kelley noted that some prediabetic mice remained healthy despite insulitis.
 
 
 
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