insulitis

insulitis

 [in″su-li´tis]
cellular infiltration of the islets of langerhans, a reaction similar to that observed in autoimmune diseases.

in·su·li·tis

(in'sŭ-lī'tis),
Inflammation of the islands of Langerhans, with lymphocytic infiltration that may result from viral infection and be the initial lesion of Type 1 diabetes mellitus.
[L. insula, island, + -itis, inflammation]

insulitis

/in·su·li·tis/ (in″sdbobr-li´tis) lymphocytic infiltration of the islets of Langerhans, suggesting an inflammatory or immunologic reaction.

insulitis

[in′səlī′tis]
a lymphocytic infiltration of the pancreatic beta cells in the islets of Langerhans. The condition is associated with the development of type 1 diabetes mellitus. Also called isletitis.
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Insulitis

in·su·li·tis

(in'sŭ-lī'tis)
Inflammation of the islands of Langerhans, with lymphocytic infiltration that may result from viral infection and be the initial lesion of Type 1 diabetes mellitus.

in·su·li·tis

(in'sŭ-lī'tis)
Inflammation of the islands of Langerhans that may be the initial lesion of Type 1 diabetes mellitus.

insulitis

cellular infiltration of the islets of Langerhans, possibly in response to invasion by an infectious agent.
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References in periodicals archive ?
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and [beta]-cell destruction in NOD mice.
sup][7] The study in nonobese diabetic mice and biobreeding diabetes-prone rats indicated that sterile rats had a higher incidence of insulitis and worse beta-cell function [sup][8],[9] while the intervention of antibiotics and probiotics appeared to have preventive role on the onset of diabetes.
CD3 stains may highlight T cells within islets, so-called insulitis, in this situation.
showed insulitis in one FT1D patient's pancreas accompanied with CD8+ T cells infiltration [12].
The role of Fas ligand in the development of insulitis in nonobese diabetic mice.
The researchers found SR1001 eliminated the incidence of diabetes and minimized insulitis, which is the inflammation associated with, and destroyer of, insulin-producing cells, in the treated animals.
Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis.
11-keto-[beta]-boswellic acid (KBA) and 0-acetyl 11-keto-[beta]-boswellic acid (AKBA) prevent insulitis in two animal models with autoimmune diabetes (Shehata et al.
Preclinical work carried out by ImCyse with such peptides in a specific T1D mouse model showed that insulitis, an absolute condition for the development of T1D, is fully prevented (and/or suppressed) upon either active immunisation or passive transfer of GAD65-specific cCD4+ T cells.
1998) Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.
Mice lacking MyD88 were protected against insulitis (74), and this phenomenon depends on commensal microbes because germ-free MyD88 knockout mice develop robust diabetes.