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insulitis

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insulitis /in·su·li·tis/ (in″sdbobr-li´tis) lymphocytic infiltration of the islets of Langerhans, suggesting an inflammatory or immunologic reaction.
in·su·li·tis (ns-lts)
n.
A histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells.
insulitis
[in′səlī′tis]
a lymphocytic infiltration of the pancreatic beta cells in the islets of Langerhans. The condition is associated with the development of type 1 diabetes mellitus. Also called isletitis.
insulitis
cellular infiltration of the islets of Langerhans, possibly in response to invasion by an infectious agent.


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Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice.
Identification of antigenic epitopes on human allergens: studies with ... by David, Chella S. / Environmental Health Perspectives
But Kelley noted that some prediabetic mice remained healthy despite insulitis.
Mouse study suggests diabetes prevention by Cowen, R. / Science News
Today, the only accurate method for detecting the progression or regression of insulitis is a biopsy of the pancreas, which is almost never performed because it is an invasive and potentially risky procedure.
New Imaging Technology Shown to Detect Pancreatic Inflammation in ... by Business Wire
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