insulitis

insulitis

 [in″su-li´tis]
cellular infiltration of the islets of langerhans, a reaction similar to that observed in autoimmune diseases.

in·su·li·tis

(in'sŭ-lī'tis),
Inflammation of the islands of Langerhans, with lymphocytic infiltration that may result from viral infection and be the initial lesion of Type 1 diabetes mellitus.
[L. insula, island, + -itis, inflammation]

insulitis

/in·su·li·tis/ (in″sdbobr-li´tis) lymphocytic infiltration of the islets of Langerhans, suggesting an inflammatory or immunologic reaction.

insulitis

[in′səlī′tis]
a lymphocytic infiltration of the pancreatic beta cells in the islets of Langerhans. The condition is associated with the development of type 1 diabetes mellitus. Also called isletitis.
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Insulitis

in·su·li·tis

(in'sŭ-lī'tis)
Inflammation of the islands of Langerhans, with lymphocytic infiltration that may result from viral infection and be the initial lesion of Type 1 diabetes mellitus.

in·su·li·tis

(in'sŭ-lī'tis)
Inflammation of the islands of Langerhans that may be the initial lesion of Type 1 diabetes mellitus.

insulitis

cellular infiltration of the islets of Langerhans, possibly in response to invasion by an infectious agent.
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References in periodicals archive ?
The researchers found SR1001 eliminated the incidence of diabetes and minimized insulitis, which is the inflammation associated with, and destroyer of, insulin-producing cells, in the treated animals.
Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis.
11-keto-[beta]-boswellic acid (KBA) and 0-acetyl 11-keto-[beta]-boswellic acid (AKBA) prevent insulitis in two animal models with autoimmune diabetes (Shehata et al.
Preclinical work carried out by ImCyse with such peptides in a specific T1D mouse model showed that insulitis, an absolute condition for the development of T1D, is fully prevented (and/or suppressed) upon either active immunisation or passive transfer of GAD65-specific cCD4+ T cells.
Mice lacking MyD88 were protected against insulitis (74), and this phenomenon depends on commensal microbes because germ-free MyD88 knockout mice develop robust diabetes.
An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice.
Tip 1 DM icin hayvan modeli olan NOD farelere yuksek doz aktif D vitamini verilmesinden sonra insulitis ve diyabet gelisimini azaldigi gozlenmistir (24), (25).
The data from this animal model suggests that the development of hyperglycemia and insulitis in type 1 diabetes may be prevented through administration of an ethanolic extract of Boswellia serrata.
In NOD mice, insulitis develops at 4-5 weeks of age, followed by subclinical [beta]-cell destruction and decreased circulating insulin concentrations.
It was demonstrated that CD4+CD25+Foxp3+ T cells, preferentially affected by low dose cyclosphamide, control diabetes development in C57BL/6 cyclophosphamide treatment may lead to diabetes induction accompanied with full blown insulitis and a cell loss in susceptible male C57Bl/6 mice.
56] at the beginning of insulitis in non-obese diabetic mice could mean more an attempt of the pancreas to preserve its endocrine function than to being related to the cause of tissue damage, as the authors concluded.
The virtual diabetic mouse exhibits characteristic insulitis in the islets and develops diabetes after twelve weeks of age if untreated.