The researchers found SR1001 eliminated the incidence of diabetes and minimized insulitis
, which is the inflammation associated with, and destroyer of, insulin-producing cells, in the treated animals.
Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis
11-keto-[beta]-boswellic acid (KBA) and 0-acetyl 11-keto-[beta]-boswellic acid (AKBA) prevent insulitis
in two animal models with autoimmune diabetes (Shehata et al.
Preclinical work carried out by ImCyse with such peptides in a specific T1D mouse model showed that insulitis
, an absolute condition for the development of T1D, is fully prevented (and/or suppressed) upon either active immunisation or passive transfer of GAD65-specific cCD4+ T cells.
Mice lacking MyD88 were protected against insulitis
(74), and this phenomenon depends on commensal microbes because germ-free MyD88 knockout mice develop robust diabetes.
An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis
in non-obese diabetic mice.
Tip 1 DM icin hayvan modeli olan NOD farelere yuksek doz aktif D vitamini verilmesinden sonra insulitis
ve diyabet gelisimini azaldigi gozlenmistir (24), (25).
The data from this animal model suggests that the development of hyperglycemia and insulitis
in type 1 diabetes may be prevented through administration of an ethanolic extract of Boswellia serrata.
In NOD mice, insulitis
develops at 4-5 weeks of age, followed by subclinical [beta]-cell destruction and decreased circulating insulin concentrations.
It was demonstrated that CD4+CD25+Foxp3+ T cells, preferentially affected by low dose cyclosphamide, control diabetes development in C57BL/6 cyclophosphamide treatment may lead to diabetes induction accompanied with full blown insulitis
and a cell loss in susceptible male C57Bl/6 mice.
56] at the beginning of insulitis
in non-obese diabetic mice could mean more an attempt of the pancreas to preserve its endocrine function than to being related to the cause of tissue damage, as the authors concluded.
The virtual diabetic mouse exhibits characteristic insulitis
in the islets and develops diabetes after twelve weeks of age if untreated.