insulin-like growth factors

insulin-like growth factors (IGF),

n a group of polypeptides responsible for the activity of growth hormones, similar in chemical structure to insulin.
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Insulin-like growth factors (IGFs), especially IGF-1, are of interest because they may explain why many of the therapies that naturopathic doctors have traditionally relied upon with cancer patients may actually work.
Insulin-like growth factors and their binding proteins: biological actions.
Duguay et al [45] studied the Divergence of insulin-like growth factors I and II in the elasmobranch Squalus acanthias and observed that the prototypical IGF molecule duplicated and diverged in an ancestor of the extant gnathostomes.
Researchers from the recently released Shanghai Breast Cancer Study, which compared 1,459 women with breast cancer to 1,556 healthy women, found that those with breast cancer were less active, had a higher body mass index (particularly abdominal obesity) and had significantly higher blood levels of insulin-like growth factors and C-peptides, all factors linked to insulin resistance.
The insulin-like growth factor (IGF) is a complex system of peptide hormones (insulin-like growth factors of type 1 and 2, IGF-1 and IGF-2), cell surface receptors (insulin receptor, IR; insulin-like growth factor receptors of type 1 and 2, IGF-R1, IGF-R2) and circulating binding proteins (insulinlike growth factor binding proteins, IGF-BP 1-6).
Radioimmunological determination of insulin-like growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.
That sets off a chain of events that leads to higher levels of insulin-like growth factors, or IGFs, which promote cell growth.
Caloric restriction and 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in rats: alterations in circulating insulin, insulin-like growth factors I and II, and epidermal growth factor.
Included among these growth factors, which are also produced by cancer cells, are insulin-like growth factors and gastrin-releasing peptide.
Regulation of DNA synthesis in chicken adipocyte precursor cells by insulin-like growth factors, platelet-derived growth factor and transforming growth factor-p.
Insulin-like growth factors (IGF-1 and -2) play important roles in the uptake of amino acids and glucose, DNA synthesis, and the proliferation and differentiation of various cell types during embryogenesis (McMurtry et al.
Insulin-like growth factors (IGF) and IGF binding proteins in milk; sources and functions.
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