insulin receptor substrate protein

insulin receptor substrate protein (IRS protein),

one of a group of proteins that link cell surface insulin receptors to intracellular signaling cascades.
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Targets prediction revealed that miR-92a targeted both GATA family of zinc finger transcription factor GATA-binding factor 6 (GATA6) and insulin receptor substrate proteins 2 (IRS-2).
Thus, it has been shown that the activated phosphorylated insulin receptor binds and phosphorylates insulin receptor substrate proteins and Shc, which in turn bind differentially to various downstream signaling proteins (Virkamaki et al.

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