insulin deficiency, acute

insulin deficiency, acute

characteristic of uncontrolled type 1 diabetes mellitus, causing hyperglycaemia (due to unrestrained hepatic gluconeogenesis, decreased glucose uptake in insulin-sensitive tissues, increased secretion of counterregulatory hormones [glucagon, cortisol, catecholamine and growth hormone]), accelerated fat breakdown (lypolysis), release of non-esterified fatty acids into circulation, ketone production and resultant ketoacidosis