insulin aspart

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insulin aspart (rDNA origin)


insulin aspart and insulin aspart protamine

NovoLog Mix 70/30

Pharmacologic class: Pancreatic hormone

Therapeutic class: Hypoglycemic

Pregnancy risk category C


Short-acting insulin form. Promotes glucose transport, which stimulates carbohydrate metabolism in skeletal and cardiac muscle and adipose tissue. Also promotes phosphorylation of glucose in liver, where it's converted to glycogen. Directly affects fat and protein metabolism, stimulates protein synthesis, inhibits release of free fatty acids, and indirectly decreases phosphate and potassium.


Injection (NovoLog): 100 units/ml in 10-ml vials and 3-ml PenFill cartridges

Injection (NovoLog Mix 70/30): 100 units/ml in 10-ml vials, 3-ml PenFill cartridges, and 3-ml FlexPen prefilled syringes

Indications and dosages

Type 1 (insulin-dependent) diabetes mellitus; type 2 (non-insulin-dependent) diabetes mellitus

Adults and children ages 6 and older: Insulin aspart-Dosage tailored to patient's needs, given subcutaneously in divided doses 5 to 10 minutes before meals. Insulin aspart provides 50% to 70% of dose; intermediate or long-acting insulin provides remainder. Dosage range is 0.5 to 1 unit/kg/day in divided doses based on meals. Insulin aspart and insulin aspart protamine- Give subcutaneously b.i.d., 15 minutes before morning and evening meals. For monotherapy, initial dosage is 0.4 to 0.6 unit/kg/day in two divided doses. Titrate in increments of 2 to 4 units q 3 to 4 days to achieve target fasting plasma glucose level. When given with oral hypoglycemics, initial dosage is 0.2 to 0.3 unit/kg/day.


• Hypersensitivity to drug or its components

• Hypoglycemia


Use cautiously in:

• hepatic or renal impairment, hypothyroidism, hyperthyroidism

• elderly patients

• pregnant or breastfeeding patients

• children.


Be aware that insulin is a high-alert drug.

• Know that drug is bioavailable as regular human insulin but has a faster onset and shorter duration.

• Give by subcutaneous route only, 5 to 10 minutes (15 minutes for Novolog Mix 70/30) before a meal.

• When mixing insulin aspart with intermediate or long-acting insulin, draw up insulin aspart into syringe first.

Don't mix insulin aspart protamine with any other insulin.

• When giving insulin aspart by pump, don't mix with other insulins.

• Rotate injection sites to prevent lipodystrophy.

Adverse reactions

Metabolic: hypokalemia, sodium retention, hypoglycemia, rebound hyperglycemia (Somogyi effect)

Musculoskeletal: myalgia

Skin: urticaria, rash, pruritus

Other: edema; lipodystrophy; lipohypertrophy; redness, warmth, or stinging at injection site; allergic reactions including anaphylaxis


Drug-drug. Acetazolamide, albuterol, antiretrovirals, asparaginase, calcitonin, corticosteroids, cyclophosphamide, danazol, dextrothyroxine, diazoxide, diltiazem, diuretics, dobutamine, epinephrine, estrogens, hormonal contraceptives, isoniazid, morphine, niacin, phenothiazines, phenytoin, somatropin, terbutaline, thyroid hormones: decreased hypoglycemic effect

Anabolic steroids, angiotensin-converting enzyme inhibitors, calcium, chloroquine, clofibrate, clonidine, disopyramide, fluoxetine, guanethidine, mebendazole, MAO inhibitors, octreotide, oral hypoglycemics, phenylbutazone, propoxyphene, pyridoxine, salicylates, sulfinpyrazone, sulfonamides, tetracyclines: increased hypoglycemic effect

Beta-adrenergic blockers (nonselective): masking of some hypoglycemia signs and symptoms, delayed recovery from hypoglycemia

Lithium carbonate: decreased or increased hypoglycemic effect

Pentamidine: increased hypoglycemic effect, possibly followed by hyperglycemia

Drug-diagnostic tests. Glucose, inorganic phosphate, magnesium, potassium: decreased levels

Liver and thyroid function studies: test interference

Urine vanillylmandelic acid: increased level

Drug-herbs. Basil, bee pollen, burdock, glucosamine, sage: altered glycemic control

Chromium, coenzyme Q10, dandelion, eucalyptus, fenugreek, marshmallow: increased hypoglycemic effect

Garlic, ginseng: decreased blood glucose level

Drug-behaviors. Alcohol use: increased hypoglycemic effect

Marijuana use: increased blood glucose level

Smoking: increased blood glucose level, decreased response to insulin

Patient monitoring

• Monitor blood glucose level frequently to gauge drug efficacy and appropriateness of dosage.

• Watch blood glucose level closely if patient is converting from one insulin type to another or is under unusual stress (as from surgery or trauma).

Stay alert for signs and symptoms of hypoglycemia. Keep glucose source at hand.

Assess for evidence of hyperglycemia, such as polydipsia, polyphagia, polyuria, and diabetic ketoacidosis (as shown by urine and blood ketones, metabolic acidosis, extremely elevated blood glucose level, and hypovolemia).

• Monitor for glycosuria.

• Closely monitor kidney and liver function test results in patients with renal or hepatic impairment.

Patient teaching

• Teach patient how to administer insulin subcutaneously or by injection pen.

• If patient must mix insulin aspart with intermediate or long-acting insulin, instruct him to draw up insulin aspart into syringe first.

Tell patient not to mix any other insulin with mixture of insulin aspart and insulin aspart protamine.

• Advise patient to rotate subcutaneous injection sites and keep a record of sites used, to help prevent fatty tissue breakdown.

Teach patient how to recognize and report signs and symptoms of hypoglycemia and hyperglycemia. Advise him to always carry a glucose source.

• Inform patient that changes in diet, activity, and stress level affect blood glucose levels and insulin requirements.

• Teach patient how to monitor and record blood glucose level and, if indicated, urine glucose and ketone levels.

• Tell patient to wear medical identification stating that he is diabetic and takes insulin.

• Instruct patient to have regular medical, vision, and dental exams.

• Tell female patient to contact prescriber if she is pregnant or plans to become pregnant.

• Advise patient to store insulin in refrigerator, not freezer.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

insulin aspart

A rapid-acting insulin analog whose amino acid sequence differs from that of human insulin by the substitution of aspartic acid for proline in the B chain, used in the treatment of type 1 and type 2 diabetes.

insulin aspart

a rapid-acting analog of human insulin created by recombinant DNA technology, in which an aspartate residue has been substituted for the usual proline at position 28 on the insulin B chain. It is administered subcutaneously for the treatment of diabetes mellitus.
References in periodicals archive ?
Hassanein et al7 have used IDegAsp, a new co-formulation of insulin degludec and insulin aspart, which is associated with reduced risk of hypoglycaemia compared with BIAsp 30 due to the flat pharmacokinetic profile and long duration of action of insulin degludec.
The company said that in October 2016, it had announced the receipt of a Complete Response Letter from the FDA regarding the NDA for fast-acting insulin aspart.
Faster-acting insulin aspart: earlier onset of appearance and greater early pharmacokinetic and pharmacodynamic effects than insulin aspart.
i tarafindan surekli glukoz monitorizasyon sistemi (continuous glucose monitoring system: CGMS) ile yapilan bir calismada hazir karisim insan insulinin Bifazik Insulin Aspart 30'a gore daha fazla ve daha uzun suren nokturnal hipoglisemilere neden oldugu gosterilmistir (22).
The clinical implication of the findings is that insulin aspart and insulin lispro are equally effective when used in insulin pumps to treat children and teens with type 1 diabetes, the researchers said.
A sensitive RIA that is specific for insulin lispro and an ELISA that is specific for insulin aspart have been developed (2,3).
A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON).
The trials evaluated the efficacy and safety of mealtime and after-meal faster-acting insulin aspart to reduce A1C levels and provide postprandial (after-meal) blood sugar control.
Novo Nordisk, which markets insulin aspart as Novolog.
In one of these analyses, when fear of hypoglycemia was considered, insulin aspart was associated with an incremental cost of Can$4429 per QALY compared to regular human insulin.
The aim of this study was to compare the efficacy and safety of insulin lispro premix 50/50 with insulin aspart premix 70/30 in patients with type 2 diabetes mellitus.