This clinical study is designed to investigate and compare the pharmacokinetic and glucodynamic effects of our PH20 enzyme administered with each of the three commercially available insulin analogs
," stated Doug Muchmore, M.
Cross-reactivity of three recombinant insulin analogs
with five commercial insulin immunoassays.
If approved, this basal insulin analog
will be an important addition to the Lilly portfolio as we work to provide a broad portfolio of diabetes medicines to our customers.
C[pounds sterling]With the rapid-acting APIDRAA insulin analog
, we hope to offer patients an effective treatment of choice for their overall diabetes therapy.
Insulin pump therapy, or continuous subcutaneous insulin infusion, is another option that delivers a rapid-acting insulin analog
in controlled doses to meet both basal and prandial insulin needs.
The agreement includes a technology transfer agreement regarding Medipolis GMP's manufacturing technology research project for producing a biologically active drug, a human insulin analog
Ryzodeg 70/30 is a mixture of insulin degludec, a long-acting insulin analog
, and insulin aspart, a rapid-acting human insulin analog
12) Premixed insulin aspart 70/30 or premixed insulin lispro 75/25 contain a soluble fraction of a rapid-acting insulin analog
and a crystallized fraction that releases the active insulin over a prolonged period.
Aradigm Corporation (Hayward, CA) announced that it been issued United States Patent 6,024,090 covering the delivery of inhaled insulin analogs
for treating patients with diabetes.
10) Currently, two rapid-acting insulin analogs
, insulin lispro and insulin aspart, and one long-acting insulin analog
, insulin glargine, are available (Fig.
A second short-acting recombinant insulin is insulin lispro (Humalog[R]; Eli Lilly and Company), which is a human insulin analog
created by reversing the amino acids at positions 28 (Pro to Lys) and 29 (Lys to Pro) of the B chain.
Contract awarded for Apra the purchase of insulin analog
recombinant dna glargine long-acting 100 iu / ml.