They were randomized to receive either Adept (227) or LRS (222) as intraoperative irrigations of 100 mL every 30 minutes, followed by a postoperative instillate
of 1,000 mL.
In this preclinical efficacy study, foals were treated with either ARCAD(TM) Instillate or control instillate.
ARCAD(TM) Instillate was easily and quickly instilled into the abdomen and was an effective preventative treatment for experimentally induced abdominal adhesions in pony foals.
The significant reduction in both the number and severity of adhesions observed following the use of ARCAD(TM) instillate in this preclinical study reinforces data previously obtained in other preclinical models of surgical adhesions using ARCAD(TM) Instillate.
This finding may be associated with the large volumes of both fluids as postsurgical instillates
Fucoidan is the key component of ARCAD(TM) Instillate.
The issuance of these patents is an important step in continuing to strengthen ARC's patent position around ARCAD(TM) Instillate," stated Barbara Campbell, Associate Director for the University-Industry Liaison Office at UBC.
Discovery has exploited this proprietary platform to move its lead liquid instillate
product, Surfaxin(R), into five late-stage clinical trials for critical care patients suffering from Respiratory Distress Syndromes.
The polymers included broaden the Company's pipeline and may be useful in the development of films, gels and instillates
for the treatment of surgical adhesion disease.