The recommended first-line agent is phenylephrine,  with the notable exceptions being the patient who responds to spinal anaesthesia with bradycardia and hypotension, or has undiagnosed cardiac disease and unexpectedly requires positive inotropy
Also, the high levels of NOS2 in failing myocytes appear to be, at least in part, a cause of the blunted myocardial inotropy
after [beta]-adrenergic stimulation [80, 81].
Circulating A also causes increased heart rate, cardiac output, inotropy
, vasodilatation in muscle and liver (24).
When the concentration of cGMP-inhibited phosphodiesterase is low, it increases the intracellular level of cyclic adenosine monophosphate (cAMp), which can be considered a positive inotropy
Howlett, Increases in diastolic [Ca2+] can contribute to positive inotropy
in guinea pig ventricular myocytes in the absence of changes in amplitudes of Ca2+ transients.
Tota, "Nitrite exerts potent negative inotropy
in the isolated heart via eNOS-independent nitric oxide generation and cGMP-PKG pathway activation," Biochimica et Biophysica Acta.
Management of postoperative PAH depends on its severity and the results of a careful evaluation; the acute right heart failure constitutes an emergency that demands aggressive treatment include maintenance of systemic perfusion pressure and avoidance of systemic vasodilators, optimization of cardiac inotropy
, a lung- protective ventilation strategy, and attempting to reduce right ventricular afterload with pulmonary vasodilators.
L-NAME in combination with DECC did not change the negative inotropy
, negative chronotropy and the decrease in coronary flow induced by DECC.
Adrenaline was substituted for noradrenaline to enhance inotropy
We found that TA (AqE) decoctions exerted positive inotropy
, accelerated myocyte relaxation and increased caffeine-induced contraction concentration-dependently.
This negative inotropy
of the apex relative to the base of the ventricle brings about the characteristic ballooning seen on catheterization of patients with takotsubo cardiomyopathy.
These results are compatible with known pharmacological effects of Crataegus extracts such as WS[R] 1442: Positive inotropy
by inhibition of myocardial [Na.