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initiation codon

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initiation codon
[inish′ē·ā′shən kō′don]
Etymology: L, initium, beginning, caudex, book
the triplet of nucleotides, usually adenine-uracil-guanine (AUG) or, in some cases, guanine-uracil-guanine (GUG), that in eukaryotes and archea code for methionine and in bacteria code for formylmethionine, the first amino acids in all protein sequences. Also called initiator codon, start codon.

initiation
the beginning or introduction rites. In cell biology, the first stage of transcription.

initiation codon
the codon AUG which specifies the first amino acid, methionine, in protein synthesis. Called also initiator.
initiation complex
is formed at the initiation of protein synthesis and includes initiation factors, tRNA, mRNA and the ribosomal subunit.
initiation factors (IF)
a group of proteins that are required for initiation of protein synthesis to occur.


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This occurs because of a complementarity between a sequence at the 3' end of 16S rRNA and the Shine-Dalgarno (SD) sequence just 5' to the initiation codon (Shine and Dalgarno, 1974; Gualerzi and Pon, 1990).
A second in-frame initiation codon is at nucleotide position 93-95, in the same position as the start codon of the 10,200 strain.
Even in the absence of a Shine-Dalgamo homology, for example, translational repression of the aph coding region of a mutant mRNA expressed in Streptomyces lividans is relieved when a short leader is adde d upstream of an extra 5'-terminal initiation codon [10].
 
 
 
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