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inhibitor of apoptosis protein |
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inhibitor of apoptosis protein (IAP), any of a class of proteins that play a regulatory role in apoptosis in many species by inhibiting caspase activity, which in turn blocks apoptosis. Such proteins are also expressed abnormally in many tumors. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Bax, Bak, PUMA, Noxa) and repressing antiapoptotic Bcl-2 (B-cell leukemia) proteins (Bcl-2, Bcl-XL) and inhibitor of apoptosis protein (survivin) (Bartke et al. Inhibitor of apoptosis proteins are a family of apoptosis-suppressing proteins commonly overexpressed in human cancers. Michael Berendt, Aegera President and CEO, stated, "We are very excited about the possibility of a new treatment for this devastating disease, and continue to believe that the Inhibitor of Apoptosis protein family, discovered by our founders, plays a central role in multiple disease indications. |
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