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inhibitor of apoptosis protein

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inhibitor of apoptosis protein (IAP),
any of a class of proteins that play a regulatory role in apoptosis in many species by inhibiting caspase activity, which in turn blocks apoptosis. Such proteins are also expressed abnormally in many tumors.


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Bax, Bak, PUMA, Noxa) and repressing antiapoptotic Bcl-2 (B-cell leukemia) proteins (Bcl-2, Bcl-XL) and inhibitor of apoptosis protein (survivin) (Bartke et al.
Michael Berendt, Aegera President and CEO, stated, "We are very excited about the possibility of a new treatment for this devastating disease, and continue to believe that the Inhibitor of Apoptosis protein family, discovered by our founders, plays a central role in multiple disease indications.
The study demonstrated that the X-linked inhibitor of apoptosis protein (XIAP) is one of the critical factors in conferring chemotherapy resistance in human prostate cancer cells.
 
 
 
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