inflammatory bowel disease


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inflammatory bowel disease

 
any of various inflammatory diseases of the bowel whose etiology is unknown, including crohn's disease and ulcerative colitis.

inflammatory bowel disease (IBD),

general term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, of unknown cause, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

inflammatory bowel disease

n. Abbr. IBD
Any of several chronic disorders of the gastrointestinal tract, especially Crohn's disease and ulcerative colitis, characterized by inflammation and ulceration of the intestine and resulting in abdominal cramping and diarrhea.

inflammatory bowel disease

inflammatory bowel disease

A general term for the symptoms associated with specific types of inflammation of the large intestine, including Crohn's disease–CD, ulcerative colitis–UC as well as idiopathic inflammatory bowel disease, a diagnosis of exclusion that clinically and pathologically mimics and/or overlaps CD and UC Heredity First-degree relatives of Pts with CD and UC have an 8- to 10-fold ↑ risk of developing the same form of colitis DiffDx Ischemia, radiation, uremia, cytotoxic drugs, heavy metal intoxication; IBD Pts often have ≥ 2 of following: Visible abdominal distension, relief of pain upon defecation, looser and more frequent bowel movements when the pain occurs; ♂:♀ ratio, 2:1; more common in Jews; IBD is associated with mucocutaneous disease–pyoderma gangrenosa, erythema nodosum, oral ulcers, annular erythema, vascular thromboses, epidermolysis bullosa, ocular disease–uveitis, iridocyclitis, hepatopathy–CAH, cirrhosis, sclerosing cholangitis, arthropathy–ankylosing spondylitis. Cf Irritable bowel syndrome Treatment Corticosteroids—or corticotropin–favored by some clinicians, aminosalicylates–sulfasalazine and 5-aminosalicylic acid, immunomodulatory agents–azathioprine, mercaptopurine, cyclosporine, MTX, metronidazole, antibiotics and nutritional support–both more effective in Crohn's disease, resulting in ↓ Sx, ↓ inflammatory sequelae, improved nutritional status.
Inflammatory bowel disease  
Clinical  Ulcerative colitis Crohn's disease
Rectal bleeding  Common  Rare
Abdominal mass  Rare  10-15%
Abdominal pain  Left-sided  Right-sided
Abnormal endoscopy  95%  < 50%
Perforation  12%  4%
Colon carcinoma  5-10%  Rare
Response to steroids  75%  25%
Surgical outcome Excellent  Fair
Rectal involvement  > 95%  !0%
Radiology
Ileal involvement  Rare  Usual
Cross-hatched ulcers  Rare  Occasional
Thumbprinting  Absent  Common
Fissuring  Absent  Common
Skip areas  Absent  Common
Strictures  Absent  Common
Pathology
Distribution  Diffuse  Focal
   Superficial  Transmural
Mucosal atrophy Regeneration  Marked Minimal
Hyperemia  Often marked  Minimal
Crypt abscess  Common  Rare
Cytoplasmic mucin  Decreased  Intact
Lymphoid aggregates  Rare  Common
Lymph nodes  Reactive hyperplasia  -----
Edema  Minimal Marked
Granulomas  Absent  60%  

in·flam·ma·to·ry bow·el dis·ease

(IBD) (in-flam'ă-tōr-ē bow'ĕl di-zēz')
General term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, autoimmune, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

Inflammatory bowel disease (IBD)

Ulcerative colitis or Crohn's colitis; chronic conditions characterized by periods of diarrhea, bloating, abdominal cramps, and pain, sometimes accompanied by weight loss and malnutrition because of the inability to absorb nutrients.

inflammatory

pertaining to or emanating from inflammation.

inflammatory bowel disease
an idiopathic disease of cats, principally, and dogs characterized by cyclic bouts of vomiting and or diarrhea which may continue over periods of years; see also lymphocytic-plasmacytic enteritis.
inflammatory edema
a disease of the subcutis caused usually by Clostridium spp.
inflammatory response
References in periodicals archive ?
Incidence of Pediatric Inflammatory Bowel Disease in Finland: An Environmental Study.
Inflammatory bowel disease is hard to treat even with strong anti-inflammatory drugs such as steroids, so talk therapy may not be strong enough.
Immunogenicity of influenza vaccine for patients with inflammatory bowel disease on maintenance infliximab therapy: a randomized trial.
A meta-analysis on the influence of inflammatory bowel disease on pregnancy.
European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease.
Inflammatory bowel disease is a life-long condition for which there is no cure.
Findings may occur at any age in inflammatory bowel disease, but the disease onset is mostly observed in the late adolescence-early adulthood.
Identify and understand important and diverse types of therapeutics under development for Inflammatory Bowel Disease.
They evaluated short-chain fatty acids, because bacterial species that make large amounts of these molecules are in short, supply in some people with inflammatory bowel disease.
A 4-year-old 4-kg sexually intact male Yorkshire Terrier was referred to the Veterinary Medicine Teaching Hospital of the Complutense University of Madrid for a re-evaluation of inflammatory bowel disease.
The forms of inflammatory bowel disease are widely prevalent in the UK and affect almost a quarter of a million people.
Medical Center, Israel) compile 13 articles on pediatric chronic inflammatory bowel disease, its genetics, epidemiology, pathology and pathogenesis, diagnosis through imaging and endoscopy, and disease management through pharmacological, nutritional, and surgical approaches.

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