AC-203 is a proprietary topical formulation of 1% diacerein, which has shown the ability to inhibit the production and activity of caspase-1 and the cytokine Interleukin-1Beta (IL-1Beta) through the inhibition of the assembly of the NLRP3 inflammasome
Messenger RNA for the NLRP3 inflammasome
is up-regulated in blood from AD patients.
In these subjects, the researchers found genetic evidence of the involvement of a so-called inflammasome
CAPS are a spectrum of diseases arising from the gain of function mutations in NLRP3, a key component of the inflammasome
, resulting in elevated systemic IL-beta levels.
acnes "is a clear instigator in eliciting a host inflammatory response," through its recognition by toll-like receptors and the inflammasome
to induce inflammation, Dr.
Activation and regulation of the NLRP3 inflammasome
Involvement of NLRP3 inflammasome
in CVB3-induced viral myocarditis.
In the renal interstitium, myoglobin could directly activate macrophages with the overexpression of the inflammasome
component (NLRP3) and proinflammatory factors (IL-1[sz]),[sup] which was consistent with our results.
The underlying pathophysiology of PRES complicated with autoimmune diseases are as follows: theories including dysfunction of autoregulatory cerebral perfusion mechanisms and endothelia, inflammasome
activation of interleukin-18 and neutrophil extracellular trap formation and the presence of autoantibodies (N-methyl-D-aspartate receptor and anti-aquaporin 4) were studied.
These diseases are characterized through clinical findings including excessive inflammasome
activation, recurrent fever episodes, eruption, urticarial rash, serositis, lymphadenopathy, and arthritis, which occur as a result of disorders of the innate immune system.
The Nlrp3 inflammasome
is critical for aluminium hydroxide-mediated IL-1[beta] secretion but dispensable for adjuvant activity.
2+] influx through TRPM2 widely contributes to inflammatory responses via chemokine production in monocytes and macrophages, (29, 30) neutrophil adhesion during myocardial ischaemia/reperfusion injury, (31) and NLRP3 inflammasome
activation in macrophages.