inflammasome

inflammasome

A multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins. The best studied of these pro-inflammatory protein complexes are NALP1 inflammasome and NALP3 inflammasome. Inflammasomes co-operate with Toll-like receptors to respond appropriately to pathogenic triggers and metabolic or genotoxic stresses, by processing interleukins and promoting the inflammatory response. Dysegulation or mutations in the genes’ encoding components of the inflammasome complex are associated with auto-immunity problems.

inflammasome

(in-flam′ă-sōm″) [ inflamma(tion) + -some]
A cytoplasmic complex that regulates the activation of caspase enzymes, which convert interleukins from their inactive forms to active forms.

inflammasome

A complex of proteins found in macrophages and neutrophils with a fundamental role in the production of inflammation in innate immunity. The NALP 1 and NALP 3 members of the NALP family of proteins (nacht domain-, leucine-rich repeat-, and pyd-containing proteins) are the main components of the inflammasome. NAPL3 (cryopyrin) is the central element in the cryopyrin inflammasome. Activation of cryopyrin by bacteria or urate crystals (as in gout) sets off a cascade of events leading to inflammation.
References in periodicals archive ?
AC-203 is a proprietary topical formulation of 1% diacerein, which has shown the ability to inhibit the production and activity of caspase-1 and the cytokine Interleukin-1Beta (IL-1Beta) through the inhibition of the assembly of the NLRP3 inflammasome.
Messenger RNA for the NLRP3 inflammasome is up-regulated in blood from AD patients.
In these subjects, the researchers found genetic evidence of the involvement of a so-called inflammasome.
CAPS are a spectrum of diseases arising from the gain of function mutations in NLRP3, a key component of the inflammasome, resulting in elevated systemic IL-beta levels.
acnes "is a clear instigator in eliciting a host inflammatory response," through its recognition by toll-like receptors and the inflammasome to induce inflammation, Dr.
Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis.
In the renal interstitium, myoglobin could directly activate macrophages with the overexpression of the inflammasome component (NLRP3) and proinflammatory factors (IL-1[sz]),[sup][5] which was consistent with our results.
The underlying pathophysiology of PRES complicated with autoimmune diseases are as follows: theories including dysfunction of autoregulatory cerebral perfusion mechanisms and endothelia, inflammasome activation of interleukin-18 and neutrophil extracellular trap formation and the presence of autoantibodies (N-methyl-D-aspartate receptor and anti-aquaporin 4) were studied.
These diseases are characterized through clinical findings including excessive inflammasome activation, recurrent fever episodes, eruption, urticarial rash, serositis, lymphadenopathy, and arthritis, which occur as a result of disorders of the innate immune system.
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1[beta] secretion but dispensable for adjuvant activity.
2+] influx through TRPM2 widely contributes to inflammatory responses via chemokine production in monocytes and macrophages, (29, 30) neutrophil adhesion during myocardial ischaemia/reperfusion injury, (31) and NLRP3 inflammasome activation in macrophages.