spermatogenic failure type 5

(redirected from infertility associated with multi-tailed spermatozoa and excessive DNA)

spermatogenic failure type 5

An infertility disorder (OMIM:243060) caused by defects of spermatogenesis. Semen from affected men show nearly 100% morphologically abnormal multiflagellar spermatozoa, with low motility, oversized irregular heads, and abnormal midpiece and acrosome.

Molecular pathology
Defects in AURKC (also designated STK13), which encodes a serine/threonine-protein kinase critical for the correct progression through and completion of mitosis, cause spermatogenic failure type 5.