indinavir /in·di·na·vir/ (in-di´nah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the sulfate salt in the treatment of HIV infection and AIDS.
indinavir,
indinavir
in·din·a·vir ( n-dn  -vîr)n. A protease-inhibiting drug usually used in combination with other drugs to suppress the replication of HIV. |
indinavir,
an antiretroviral protease inhibitor.
indications It is prescribed in the treatment of human immunodeficiency virus infection.
contraindications It should not be given to patients with a risk of kidney stones. It should be administered with other medications to reduce the risk of resistance development.
adverse effects Protease inhibitors increase plasma glucose, cholesterol, and triglyceride levels and cause a redistribution of body fat toward the center. Indinavir also can cause nephrolithiasis and hyperbilirubinemia.
indinavir
Crixivan®, MK-639 AIDS A potent HIV protease inhibitor used alone or with other antiretrovirals and nucleoside analogues for HIV Pts with ↓ CD4 cells Adverse effects ↑ LFTs, kidney stones, nausea,
lipodystrophy–hyperglycemia, ↑ fats, ↑ waist, ↓ fat from face, arms, legs, ↑ BR. See AIDS, HIV, Protease inhibitor.
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