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In human genetics, the patient or member of the family that brings a family under study.
Synonym(s): index case
[L. probo, to test, prove]
1. The earliest identified occurrence of a disease or disorder, usually as part of an epidemiological investigation of a patient population or a genetic study of a family.
2. The first patient who has such a disease or disorder. Also called proband, propositus.
Etymology: L, indicare, to make known
(in epidemiology) the first case of a disease, as contrasted with subsequent cases. See also propositus.
index caseSee Index patient, see there.
in·dex case(in'deks kās)
The first case in the investigation of the outbreak of a potentially epidemic disease.
The first case of a contagious disease in a group or population that serves to call attention to the presence of the disease.
Mentioned in: Syphilis
in epidemiology, an animal which has the specified disease or condition which is under investigation.
a structured summary of a case report suitable for computer entry; permits machine sorting and retrieval and leads an investigator to the original paper records on which detailed descriptions must be based.
selection of cases as a sample to use in a case-control study (below).
a retrospective, analytical, epidemiological study. A group of pre-existing cases of the disease are matched with a selected group of control animals that do not have the disease so that the presence or otherwise of an hypothesized disease determinant can be ascertained in both groups.
case fatality rate
the proportion of cases with a specified condition which die within a specified time.
the strategy of surveying a population to find the sick animals that are the foci of infection; an essential early step in the eradication of any disease.
the collected data concerning an individual, contact and related animals, environment and management procedures, including any past medical history and any other information that may be useful in analyzing and diagnosing the case or for instructional or research purposes.
the first case recorded in an outbreak.
care of a sick animal including specific and supportive medication, surgical intervention, housing, bedding, nutrition, restraint, collection of specimens for submission to laboratory or stall-side tests.
the group of animals in the total population which are sick or infected, as distinct from the control population, which are not sick or infected.
entry in records of the clinical findings of individual sick animals. May be structured or unstructured, paper or machine, with or without the accounting record for the case.
pl. indexes, indices [L.] the numerical ratio of measurement of any part in comparison with a fixed standard.
the first case of a disease in a group to be brought to the attention of the clinician.
a publication of the Society of Dyers and Colorists and the American Association of Textile Chemists and Colorists, containing an extensive list of dyes and dye intermediates. Each chemically distinct compound is identified by a specific number, the CI number, avoiding the confusion of trivial names used for dyes in the dye industry. The Royal Horticultural Society, London, produces a similar document to aid in the identification of flower colors.
see erythrocyte indices.
a monthly publication of the National Library of Medicine, in which the world's leading biomedical literature is indexed by author and subject.
a measure of opsonic activity determined by the ratio of the number of microorganisms phagocytized by normal leukocytes in the presence of serum from an animal infected by the microorganism, to the number phagocytized in serum from a normal animal.
the average number of bacteria ingested per leukocyte of the patient's blood.
a method of expressing production compared with a potential or target.
the refractive power of a medium compared with that of air (assumed to be 1).
originally, the ratio of the maximum tolerated dose to the minimum curative dose; now defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50). It is used in assessing the safety of a drug.
a periodic listing of all publications in the veterinary literature by the Commonwealth Agricultural Bureaux, United Kingdom. Also available on on-line data search.
the ratio of births to deaths within a given time in a population.