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incomplete penetrance

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.03 sec.
penetrance
the frequency with which a heritable trait is manifested by individuals carrying the principal gene or genes conditioning it.

incomplete penetrance
when penetrance is less than 100%.

incomplete penetrance
adjective Referring to the presence of a gene that is not phenotypically expressed in all members of a family with the gene. See Penetrance.


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Each child has a 50% risk of inheriting the predisposing mutation (not everyone with the mutation will develop cancer because of incomplete penetrance and gender-related expression).
DIAGNOSIS Von Hippel-Lindau disease DISCUSSION Von Hippel-Lindau disease is an autosomal dominant disorder that shows an incomplete penetrance (the gene is inherited, but not always expressed).
Although genetic variants and their interactions probably define most interindividual variability in common disease susceptibility related to genetics (Moore 2003; Newton-Cheh and Hirschhorn 2005), they generally possess low or incomplete penetrance and consequently show low-risk associations in epidemiologic studies [e.
 
 
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