incompatible combinations of clinical medicaments

incompatible combinations of clinical medicaments

Table 1 and Table 2
Table 1: Incompatibilities of clinical medicaments
Physical incompatibilityOils and water
Compound tincture of benzoin (TBCo) and water
Chemical incompatibilityNeutralization
(e.g. salicylic acid and sodium bicarbonate)
Inhibition
(e.g. adrenaline with alkalis/hydrogen peroxide, iron salts; cetrimide or chlorhexidine with soap; iodine with chloroxylenol or starch)
Formation of an inactive precipitate
(e.g. silver nitrate with sodium chloride or potassium iodide; benzoic acid with ferric chloride; ferric chloride with iodine preparations, salicylic acid or tannic acid; sodium chloride with iodine preparations)
Formation of a toxic substance
(e.g. mercury salts and iodine)
Formation of an explosive substance
(e.g. potassium permanganate with organic solvents; nitric acid with glycerin)
Table 2: Neutralizing the action of topical medicaments
Agent/medicamentNeutralizing chemical
Acids
e.g. monochloroacetic acid, trichloroacetic acid, salicylic acid, nitric acid
Alkalis
e.g. potassium hydroxide 5% solution; 1:80 bicarbonate of soda solution
Alkalis
e.g. potassium hydroxide
Weak acids
e.g. dilute vinegar; acetic acid solution
Phenol
e.g. 80% liquefied phenol solution
Industrial methylated spirit (IMS) (to dilute phenol), followed by glycerin, or bicarbonate of soda, or weak iodine solution
Glycerin (to skin burned by phenol application)
Silver nitrate
e.g. 5-75% silver nitrate
Normal saline (0.9% NaCl solution) or weak iodine solution, or weak ferric chloride solution
Iodine
e.g. weak iodine (2.5% mitis) solution; strong iodine (10% fortis) solution
Starch paste or sodium thiosulphate 20% solution, or chloroxylenol 5% (Dettol) solution