inclusion body


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Related to inclusion body: inclusion body disease

inclusion body

n.
An abnormal structure in a cell nucleus or cytoplasm having characteristic staining properties and usually composed of protein, occurring primarily in infectious diseases, especially viral infections such as rabies.

inclusion body

A generic term for a circumscribed mass of intracellular or intranuclear material, which is often “foreign” to the cell or nucleus.

Examples
Metal (e.g., lead, mercury); viral particles (e.g., herpes, CMV); metabolically inactive materials (e.g., ceroid, Mallory bodies).

inclusion body

  1. a body present in the nuclei or cytoplasm of cells infected by viruses or other intracellular parasites.
  2. an insoluble protein aggregate that may form a crystalline structure inside host cells. An inclusion body may form as a result of overproduction of recombinant or normal protein in an overexpression system (see GENE EXPRESSION).

inclusion body

extraneous (e.g. viral) material within cell cytoplasm or nucleus

inclusion body

round, oval or irregular-shaped bodies in the cytoplasm and nucleus of cells, as in diseases due to viral infection, such as rabies, inclusion body rhinitis. May be acid-fast as in lead poisoning. See also bollinger bodies, borrel bodies, elementary body (1), guarnieri bodies, joest bodies, Negri body, paschen bodies and type A, type B inclusion bodies (below).

falcon inclusion body disease
caused by a herpesvirus, the clinical signs include weakness, anorexia, diarrhea and a mortality rate of 100%. There is a profound leukopenia.
inclusion body hepatitis
a disease of young chickens caused by an adenovirus and characterized by jaundice and anemia. The mortality rate is about 25%. Called also chicken hemorrhagic syndrome.
inclusion body rhinitis
a disease of the upper respiratory tract of young pigs caused by a cytomegalovirus. Clinically there is paroxysmal sneezing, a serous, ocular and nasal discharge, and a benign course. It may be a precursor to atrophic rhinitis.
snake inclusion body disease
thought due to a virus; observed in many boid snakes; characterized by heavy mortality after signs of CNS disease; inclusion bodies in most tissues, especially brain.
type A inclusion body
found in chromatically disrupted nuclei with margination of the chromatin fragments and the inclusion body is amorphous or granular and acid-staining; characteristic of cells infected with, for example, herpesvirus and adenovirus.
type B inclusion body
the nucleus is still well organized, there is no margination of chromatin and the inclusion bodies are well defined; seen in cells infected with, for example, distemper virus.
References in periodicals archive ?
The pathogenesis of inclusion body myositis may involve immune dysfunction.
Sporadic inclusion body myositis and hereditary inclusion body myositis.
Mitochondrial DNA deletions in muscle fibers in inclusion body myositis.
Drugs Profiles cover in this report are AAV1-Foliistatin, ACE-083, aceneuramic acid, bimagrumab, DEXM-74, Gene Therapy for Hereditary Inclusion Body Myopathy and UX-007.
FUS pathology in basophilic inclusion body disease.
The snake is completely healthy and has never had contact with snakes infected with inclusion body disease, says Freeland Dunker, a veterinarian at the academy.
Hereditary inclusion body myopathy--This causes progressive weakness in the arms and legs.
A generalized inclusion body disease in the budgerigar (Melopsittacus undulatus) caused by a papovavirus-like agent.
1) Other reasons for non-response include alternative diagnoses, such as inclusion body myositis, or an underlying malignancy.
He had been all but housebound for many years with a curious disease called Inclusion Body Myocitis (or IBM for short) which caused the muscles in his legs to all but disappear.
The eosinophilic proximal tubular nuclear inclusion body, once thought to be pathognomonic of lead nephropathy, is present only during the early years of lead exposure.
du Pont de Nemours and Company (Wilmington, DE) has patented peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides.