inclusion body

inclusion body

n.

An abnormal structure in a cell nucleus or cytoplasm having characteristic staining properties and associated especially with certain viral infections, such as rabies and smallpox.

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inclusion body

round, oval or irregular-shaped bodies in the cytoplasm and nucleus of cells, as in diseases due to viral infection, such as rabies, inclusion body rhinitis. May be acid-fast as in lead poisoning. See also bollinger bodies, borrel bodies, elementary body (1), guarnieri bodies, joest bodies, Negri body, paschen bodies and type A, type B inclusion bodies (below).

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falcon inclusion body disease

caused by a herpesvirus, the clinical signs include weakness, anorexia, diarrhea and a mortality rate of 100%. There is a profound leukopenia.

inclusion body hepatitis

a disease of young chickens caused by an adenovirus and characterized by jaundice and anemia. The mortality rate is about 25%. Called also chicken hemorrhagic syndrome.

inclusion body rhinitis

a disease of the upper respiratory tract of young pigs caused by a cytomegalovirus. Clinically there is paroxysmal sneezing, a serous, ocular and nasal discharge, and a benign course. It may be a precursor to atrophic rhinitis.

snake inclusion body disease

thought due to a virus; observed in many boid snakes; characterized by heavy mortality after signs of CNS disease; inclusion bodies in most tissues, especially brain.

type A inclusion body

found in chromatically disrupted nuclei with margination of the chromatin fragments and the inclusion body is amorphous or granular and acid-staining; characteristic of cells infected with, for example, herpesvirus and adenovirus.

type B inclusion body

the nucleus is still well organized, there is no margination of chromatin and the inclusion bodies are well defined; seen in cells infected with, for example, distemper virus.