inactivated

poliovirus vaccine, inactivated.

See poliovirus vaccine.

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inactivated

rendered inactive; the activity is destroyed.

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inactivated viruses

treated so that they are no longer able to produce evidence of growth or damaging effect on tissue. Inactivation may be by physical means including heat, ultraviolet light, ultrasonic vibration, or by chemical treatment. Used in inactivated viral vaccines.

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Creutzfeldt-Jakob disease

Spastic pseuodoparalysis, subacute spongiform encephalopathy Neurology An invariably fatal, kuru-like infection which causes a form of presenile dementia primarily affecting middle-aged adults, caused by an aberrant protein, a prion Clinical 2-4 yrs after exposure → pyramidal tract disease with Babinski sign, nervousness, loss of facial expression; cerebellar dysfunction with ataxia, myoclonus, unsteady gait; basal ganglia involvement is manifest by rigidity, bradykinesia, intention tremor, dystonic postures, choreoathetosis, muscle spasms, imbalance, dementia Prognosis No treatment, no cure; CJD progresses rapidly to coma and death in 3 to 12 months. See Bovine spongiform encephalopathy, Kuru, Prion, Scrapie.

Creutzfeld-Jakob disease agent–disinfection

Inactivated by autoclaving for 1 hour at 132ºC and 20 psi, 5% hypochlorite, and 0.03% permanganate solutions. Instruments 0.1 N sodium hydroxide for 2 hours; 5% bleach–NaOCl for 4 hours; all surfaces should be scrubbed with iodine or phenol-based detergents

NOT inactivated by boiling, 10% formalin, 70% alcohol, UV light