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inactivated |
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poliovirus vaccine, inactivated. See poliovirus vaccine. inactivated rendered inactive; the activity is destroyed. inactivated viruses treated so that they are no longer able to produce evidence of growth or damaging effect on tissue. Inactivation may be by physical means including heat, ultraviolet light, ultrasonic vibration, or by chemical treatment. Used in inactivated viral vaccines. Creutzfeldt-Jakob disease Spastic pseuodoparalysis, subacute spongiform encephalopathy Neurology An invariably fatal, kuru-like infection which causes a form of presenile dementia primarily affecting middle-aged adults, caused by an aberrant
protein, a prion Clinical 2-4 yrs after exposure → pyramidal tract disease with Babinski sign, nervousness, loss of facial expression; cerebellar dysfunction with ataxia, myoclonus, unsteady gait; basal ganglia involvement is manifest by
rigidity, bradykinesia, intention tremor, dystonic postures, choreoathetosis, muscle spasms, imbalance, dementia Prognosis No treatment, no cure; CJD progresses rapidly to coma and death in 3 to 12 months. See Bovine spongiform encephalopathy, Kuru, Prion, Scrapie.
Creutzfeld-Jakob disease agent–disinfection
Inactivated by autoclaving for 1 hour at 132ºC and 20 psi, 5% hypochlorite, and 0.03% permanganate solutions. Instruments 0.1 N sodium hydroxide for 2 hours; 5% bleach–NaOCl for 4 hours; all surfaces should be scrubbed with iodine
or phenol-based detergents
NOT inactivated by boiling, 10% formalin, 70% alcohol, UV light
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We have developed an inactivated virus vaccine that induces neutralizing antibodies and protects against SARS-CoV challenge. In this position, he managed sales and marketing operations for Merck's line of live virus and inactivated human vaccines in more than 17 countries. Stedman of the University of Pennsylvania School of Medicine in Philadelphia found that only people possess an inactivated version of a gene involved in facial-muscle movements. |
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