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immunosuppressants |
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immunosuppressants, n.pl the agents that lower or reduce immune response; useful in organ transplant surgery to prevent organ rejection. Corticosteroid hormones given in large amounts; cytotoxic drugs, including antimetabolites and alkylating agents; antilymphocytic serum; and irradiation may result in immunosuppression.
immunosuppressants Drugs that prevent or reduce the immune response. They are used in the treatment of a variety of severe inflammations such as uveitis, scleritis, keratoconjunctivitis sicca, Behçet's syndrome, sympathetic ophthalmia, and to prevent corneal graft rejection. They include the corticosteroids (e.g. prednisolone), ciclosporin (cyclosporine), tacrolimus, and cytotoxic agents (e.g. azathioprine, chlorambucil, cyclophosphamide, methotrexate). It must be noted that immunosuppressants render the patient more susceptible to infection because immunity is reduced. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The long-term use of immunosuppressants, danger of infection, high cost, scarcity of donors and unknown side effects, however, are problems that have yet to be solved, meaning that the quality of life (QOL) of patients is markedly reduced. The new Medicare drug coverage will rely on restrictive formularies as a cost-containment measure, although the federal government has promised substantial access to antidepressants, antipsychotics, anticonvulsants, HIV/AIDS drugs, cancer medications, and immunosuppressants (all of which could be subject to utilization controls, such as prior-authorization and step therapy mandates). Other recent research may lead to improved dosing for the immunosuppressants cyclosporine and tactolimus, which can cause kidney damage and failure. |
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