immunosenescence


Also found in: Wikipedia.

immunosenescence

(ĭm″ū-nō-sĭ-nĕs′ĕns)
The age-associated decline of the immune system and host defense mechanisms. Elderly individuals frequently have a decline in cell-mediated immunity and secondary declines in humoral immunity. The clinician caring for an older patient can assume that the individual has defective host defenses, is at greater risk for developing an infectious disease, and has an increased risk of morbidity and mortality from infectious diseases.
References in periodicals archive ?
This age-related reduction in immune system vigilance is called immunosenescence.
Elderly persons have been postulated to have an increased susceptibility to-in addition to co-ocurring conditions-pneumococcal disease because of reduced splenic function (23), age-related changes in respiratory tract, immunosenescence, and cellular senescence related to age-associated inflammation (23).
Singapore, Feb 13, 2014 - (ACN Newswire) - A*STAR's Singapore Immunology Network (SIgN) signed a three-year partnership with the National University of Singapore (NUS), National University Hospital (NUH) and Sanofi Pasteur to embark on a Phase IV clinical trial to understand age-related loss of immunity, known as immunosenescence, in elderly.
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence.
21) Most patients are thought to have age-related immunosenescence, but a subset of patients have iatrogenic immunodeficiency.
Ageing is known to affect immune function, a phenomenon known as immunosenescence, but how this happens is not clear," said study leader Laura Santambrogio, M.
We are becoming a nation of older people, and we had better focus our priorities, time, and resources on understanding immunosenescence, designing vaccines against diseases that primarily afflict the elderly, improving vaccine immunogenicity and efficacy in the elderly, and funding vaccine delivery for the elderly.
Sample article topics include: state of the art therapeutic hypothermia; HIV infection, inflammation, immunosenescence, and aging; and, mechanisms of endocrine resistance in breast cancer.
The research, published in FEMS Immunology & Medical Microbiology, reveals that daily consumption of probiotic cheese helps to tackle age-related changes in the immune system, researchers also known as immunosenescence.
A team from Finlands Turku University concluded a daily portion of probiotic cheese can slow the degeneration of our bodies known as immunosenescence, which makes it much harder to fight infections and respond to vaccinations.
Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence.