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Synthesis of immunoreactive insulin in vitro by aplastic mammary carcinoma preconditioned in diabetic mice.
The specific determination of insulin lispro offers advantages over measuring total concentrations of immunoreactive insulin and would be particularly useful in assessing the pharmacokinetics of insulin lispro in patients with insulin resistance and in documenting factitious hypoglycemia from injection of insulin lispro.
In healthy subjects, the contribution of intact proinsulin and conversion intermediates is relatively low, representing at most 10-20% of immunoreactive insulin.

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