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Related to immunoglobulins: immunoglobulin G


ANTIBODIES, protective proteins produced by cloned B lymphocyte-derived plasma cells. There are five classes of immunoglobulins, the most prevalent being immunoglobulin G (IgG), or gammaglobulin which provides the body's main defence against bacteria, viruses and toxins. Immunoglobulins are Y-shaped protein molecules consisting of two inner heavy POLYPEPTIDE chains, forming a Y, and, attached to the outer side of the short arms of the Y, two light polypeptide chains. The heavy chains are held together and the light chains held to the arms, by disulphide bonds. The short arms of the Y, with the light chains, are called the Fab (fragment antigen binding) section of the antibody. The antigen combining site lies between the open ends of the light and heavy chains. See also IgA, IgD, IgE, IgG and IgM. Some immunoglobulins are prepared as drugs for the management of RHESUS incompatibility and antibody deficiency; for the prophylaxis of MEASLES and hepatitis A; to minimize fetal damage when a pregnant woman is exposed to RUBELLA; and to assist in the treatment of TETANUS and RABIES. They are marketed under such brand names as Flebogamma, Gammabulin, Gammagard, Octagam, Rhophylac, Sandoglobulin, Vigam liquid and Winrho SDF.


Any of several types of globulin proteins that function as antibodies.

immunoglobulins (Ig) (antibodies) (im´ūnōglob´ūlinz),

serum pro-teins (g globulins) synthesized by plasma cells that act as antibodies and are important in the body's defense mechanisms against infection. See also antibody and allergen.
immunoglobulin, IgA,
n a type of immunoglobulin most commonly found in saliva, mucus, tears, urine, and other secretions.
immunoglobulin, IgD,
n a type of immunoglobulin that operates as antibodies. Trace amounts of IgD proteins are found in the blood serum and the plasma membranes of B lymphocytes.
immunoglobulin, IgE,
n a type of immunoglobulin that plays a role in regulating hypersensitivity reactions and reactions to parasitic infections.
immunoglobulin, IgG,
n a type of immunoglobulin that plays a role in secondary immune responses. It is unique in that it can pass through the placental barrier.
immunoglobulin, IgM,
n a type of immunoglobulin that reacts first to any given immune response.
References in periodicals archive ?
This report analyzes the worldwide markets for Intravenous Immunoglobulin (IVIg) in US$ Million and in Kilograms.
The low pH environment of the reaction mixture can lead to precipitation of immunoglobulins and result in increased turbidity and light scattering (5, 7).
When ghrelin was administered in combination with immunoglobulins extracted from the blood of obese patients, or with immunoglobulins derived from genetically-obese mice, they stimulated food intake more strongly.
Immunoglobulin is a glycoprotein found in blood and other body fluids that contains antibodies to protect the body against pathogens.
Immunoglobulins (IgG, IgA, and IgM) were measured on a Roche Cobas 6000 (C501 unit) using an immunoturbidimetric assay according to manufactures' methods.
28) Therefore, during cancer prognosis, levels of immunoglobulins and complements are altered markedly to compensate for the changing environment of the cancer cell.
The immunoglobulin will help produce antibodies and suppress the immune system, potentially starting the process to produce the bone marrow Cara so desperately needs.
Common variable immunodeficiency (CVID) is a condition characterized by low levels of immunoglobulin (Ig) G and either IgA or IgM in the presence of recurrent infections.
Treatment of West Nile virus encephalitis with intravenous immunoglobulin.
If they are positive, their infants get two inoculations: the first consists of hepatitis B immunoglobulins [which contain antibodies against the hepatitis B virus, providing passive immunity], and the second is the hepatitis B vaccine.
In contrast to other immunoglobulins that bind to immunoglobulin Fc receptors only when antigen has been bound by an antibody, IgE will bind to Fc[Epsilon]R in the absence of antibody.
In a two-year study of 148 patients with relapsing-remitting multiple sclerosis (MS), researchers found that those who received monthly intravenous infusions of a substance called immunoglobulin had their symptoms improve, compared with those who received placebo.

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