The feline antibody profiles were consistent with the known serologic immunodominance
of these antigens in M.
Viral persistence alters CD8 T-cell immunodominance
and tissue distribution and results in distinct stages of functional impairment.
Not every individual will generate cross-neutralizing antibodies since immunodominance
Mechanisms influencing the immunodominance
of T cell determinants.
Other probiotic strain properties, such as immunodominance
, adhesion on cell lines, and mucin and human biopsies are being studied.
The antigen-specific CD4+ response may not develop the dramatic immunodominance
hierarchies that are well-known for CD8+ T cells and may be directed at many epitopes, more than are seen in the more-delimited CD8+ T-cell response.
MHC affinity, peptide liberation, T cell repertoire, and immunodominance
all contribute to the paucity of MHC class I- restricted peptides recognized by antiviral CTL.
We did not observe a correlation between viral protein levels determined by SDS-PAGE (Figure 2, panel A) and immunodominance
by Western blot analysis (Figure 2, panel B).