After receiving an autologous stem cell transplant (SCT), she experienced a relapse of disease and was enrolled in an experimental protocol of immunoablative
chemotherapy, followed by hematopoietic SCT at the National Institutes of Health Clinical Center in Bethesda, Maryland (www.
The authors concluded that this immunoablative
regimen of cyclophosphamide for patients with aggressive MS was safe, worthy of further study and may be an alternative to bone marrow transplantation.
Evaluating the role of immunoablative
high-dose cyclophosphamide therapy in pemphigus vulgaris.
A key to the success of this program is that patients receive a conditioning regimen that is immunoablative
but not myeloablative.
The protocol involves preparing the patient with an immunoablative
regimen, taking lymphocytes from a sibling treated with granulocyte-macrophage colony-stimulating factor, transferring the lymphocytes to the patient, and then giving the patient cyclosporine.
The use of G-CSF did not induce inflammatory activity in the central nervous system; CNS antibody production decreased after immunoablative