globulin (redirected from immune human serum globulin)

globulin /glob·u·lin/ (glob´u-lin) any of a class of proteins insoluble in water, but soluble in saline solutions (euglobulins), or water-soluble proteins (pseudoglobulins); their other physical properties resemble true globulins; see serum g.

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a-globulins  serum globulins with the most rapid electrophoretic mobility, further subdivided into faster a1- and slower a2-globulins.

AC globulin , accelerator globulin coagulation factor V.

alpha globulins  a.

antihemophilic globulin  (AHG) coagulation factor VIII.

antilymphocyte globulin  (ALG) the gamma globulin fraction of antilymphocyte serum (q.v.), used as an immunosuppressant in organ transplantation.

antithymocyte globulin  (ATG) the gamma globulin fraction of antiserum derived from animals (e.g., rabbits) that have been immunized against human thymocytes; it causes specific destruction of T lymphocytes, used in treatment of allograft rejection.

ß-globulins  globulins in plasma which, in neutral or alkaline solutions, have an electrophoretic mobility between those of the alpha and gamma globulins.

bacterial polysaccharide immune globulin  (BPIG) a human immune globulin derived from the blood plasma of adult human donors immunized with Haemophilus influenzae type b, pneumococcal, and meningococcal polysaccharide vaccines; used for the passive immunization of infants under 18 months of age.

beta globulins  ß.

cytomegalovirus immune globulin  a purified immunoglobulin derived from pooled adult human plasma selected for high titers of antibody against cytomegalovirus (CMV); used for the treatment and prophylaxis of cytomegalovirus disease in transplant recipients.

?-globulins , gamma globulins serum globulins having the least rapid electrophoretic mobility; the fraction is composed almost entirely of immunoglobulins.

hepatitis B immune globulin  a specific immune globulin derived from blood plasma of human donors with high titers of antibodies against hepatitis B surface antigen; used as a passive immunizing agent.

hyperimmune globulin  any of various immunoglobulin preparations especially high in antibodies against certain specific diseases.

immune globulin 

1. immunoglobulin.

2. a concentrated preparation of gamma globulins, predominantly IgG, from a large pool of human donors; used for passive immunization against measles, hepatitis A, and varicella and for replacement therapy in patients with immunoglobulin deficiencies.

immune human serum globulin  immune g. (2).

immune globulin intravenous (human)  a preparation of immune globulin suitable for intravenous administration; used in the treatment of primary and secondary immunodeficiency states, idiopathic thrombocytopenic purpura, and Kawasaki disease.

immune serum globulin  immune g. (2).

pertussis immune globulin  a specific immune globulin derived from the blood plasma of human donors immunized with pertussis vaccine; used for the prophylaxis and treatment of pertussis.

rabies immune globulin  a specific immune globulin derived from blood plasma or serum of human donors who have been immunized with rabies vaccine and have high titers of rabies antibody; used as a passive immunizing agent.

respiratory syncytial virus immune globulin intravenous  a preparation of immunoglobulin G (IgG) from pooled adult human plasma selected for high titers of antibodies against respiratory syncytial virus; used for passive immunization of infants and young children.

Rh0(D) immune globulin  a specific immune globulin derived from human blood plasma containing antibody to the erythrocyte factor Rh0(D); used to prevent Rh-sensitization of Rh-negative females and thus prevent erythroblastosis fetalis in subsequent pregnancies; administered within 72 hours after exposure to Rh-positive blood resulting from delivery of an Rh-positive child, abortion or miscarriage of an Rh-positive fetus, or transfusion of Rh-positive blood; also used to stimulate the platelet count in idiopathic thrombocytopenic purpura.

serum globulins  all plasma proteins except albumin, which is not a globulin, and fibrinogen, which is not in the serum; they are subdivided into a-, ß-, and ?-globulins.

sex hormone–binding globulin  (SHBG) a ß in plasma that binds to and transports testosterone, and to a lesser degree estrogens.

specific immune globulin  a preparation of immune globulin derived from a donor pool preselected for a high antibody titer against a specific antigen.

tetanus immune globulin  a specific immune globulin derived from the blood plasma of human donors who have been immunized with tetanus toxoid; used in the prophylaxis and treatment of tetanus.

varicella-zoster immune globulin  (VZIG) a specific immune globulin derived from plasma of human donors with high titers of varicella-zoster antibodies; used as a passive immunizing agent.

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glob·u·lin (glby-ln)

n.

Any of a family of proteins that are precipitated from plasma by ammonium sulfate and may be further fractionated into many subgroups that differ with respect to associated lipids or carbohydrates.

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globulin (glob´ylin),

n a class of proteins.

globulin, antihemophilic,

n See factor VIII.

globulin, antihemophilic A,

n See factor VIII.

globulin, antihemophilic B,

n See factor IX.

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globulin

a general term for proteins that are insoluble in water or highly concentrated salt solutions but soluble in moderately concentrated salt solutions. All plasma proteins except albumin and prealbumin are globulins. The plasma globulins can be separated into five fractions by serum protein electrophoresis (SPE). In order of decreasing electrophoretic mobility these fractions are the alpha₁, alpha₂, beta₁ and beta₂ globulins, and the gamma globulins.

The globulins include carrier proteins, which transport specific substances; acute phase reactants, which are involved in the inflammatory process; clotting factors; complement components; and immunoglobulins. Examples are transferrin, a beta₁ globulin that transports iron, and alpha₁-antitrypsin, an acute phase reactant that inhibits serum proteases. The gamma globulin fraction is almost entirely composed of immunoglobulins.

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accelerator globulin

a substance present in plasma, but not in serum, that functions in the formation of intrinsic and extrinsic thromboplastin; called also clotting factor V.

antihemophilic globulin (AHG)

clotting factor VIII.

antilymphocyte globulin (ALG)

a substance used as an immunosuppressive agent in organ transplantation, usually in combination with immunosuppressive drugs; it is the gamma globulin fraction of antilymphocyte serum.

immune globulin

a sterile solution containing antibodies normally present in blood, derived from donor animals, sometimes after hyperimmunization with certain microorganisms; used for passive immunization against some infectious diseases and in the treatment of gamma globulin deficiency.

serum globulin

the fraction of proteins precipitated from blood serum by half saturation with ammonium sulfate; the principal groups include the a-, ß- and ?-globulins.