The goal of the therapy is to reduce the burden of circulating RNA-containing immune complexes
which are thought to be the most proximal trigger of the systemic inflammation characteristic of SLE.
Diagram 1: How Food Sensitivities Cause Inflammation Mechanisms * TLR's * Food antigens * Food chemicals * Haptens * Amines * Pharmacologic * Immune Complexes
* IgG * IgM * Lectins Cellular Activation * Lymphocytes * Sensitized T-cells * T-Cells * NK Cells * K Cells * Eosinophils * Basophils * Monocytes * Neutrophils Mediator Release * Cytokines * Interleukins * Chemokines * TNFs * Interferons * Leukotrienes * Histamine * ECP.
Detection of immune complexes
in systemic lupus erythematosus with the C1q solid phase assay: correlation with nDNA antibodies and hypocomplementemia.
consisting of autoantibodies to chromatin and RNA-protein particles (snRNP or ribonucleoproteins) are diagnostic for SLE and are thought to play an important role in the pathogenesis of the disease.
The Company thus concludes from its experiments that as a mechanism of immune escape, tumor antigens, in particular mucinous ones like CA125, may inhibit processing pathways in antigen-presenting cells, and the new data address this "defensive strategy" of tumors and demonstrate its reversal by offering antigen to the immune system in the form of immune complexes
And finally she will summarize ongoing and planned experiments by AltaRex and with others exploring the administration of immune complexes
, synergistic effects from loading dendritic cells with complexes, and the targeting of new cancer antigens including early stage disease targets like human carcinoma antigen.
The body uses these naturally-occurring enzymes to remove circulating immune complexes
from the blood and other harmful proteins to deliver nutrients and oxygen to various tissues more efficiently.
Some of the seminal contributions such as the first demonstration of impaired clearance of immune complexes
in SLE patients, the identification of the role of Fc receptors in phagocytosis, and the identification of FcGR-2A as the first human lupus gene were made by HSS investigators," said Vijay Ramakrishnan, Ph.
At the same time, immune complexes
that include murine antibodies can induce activation of dendritic cells, resulting in up-regulation of co-stimulatory molecules (e.
Subjects with established autoimmune disease experienced a reversal of symptoms, including decreased appearance of proteinuria, of circulating immune complexes
and of auto-antibodies to nuclear antigens.
In the Company's preclinical dendritic cell model, immune complexes
appear to modify antigen presentation for priming of the cellular responses necessary to effect tumor killing.
This invention to which InKine has the exclusive worldwide license may have important clinical relevance in removing immune complexes
in diseases and preventing their deposition in important organs such as the kidney," said Leonard S.