immotile cilia syndrome

immotile cilia syndrome

n.

An inherited syndrome caused by the absence of dynein structures and the subsequent inability of cilia to beat effectively and marked by recurrent sinopulmonary infections, reduced fertility in women, and sterility in men.

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immotile cilia syndrome

[imō′til]

Etymology: L, im, motilis, movable, cilia, eyelashes; Gk, syn, together, dromos, course

a condition in which cilia, the hairlike processes of epithelial cells, fail to function normally. As a result, the patient has difficulty in filtering dust and other airborne debris from the respiratory system. See also Kartagener's syndrome.

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immotile cilia syndrome

congenital defect of ciliary movement recorded in dogs. See also primary ciliary dyskinesia, kartagener's syndrome.

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immotile cilia syndrome

Kartagener syndrome An uncommon–1:20 000 AR disease of childhood onset due to defective or afunctional cilia in the respiratory tract, resulting in chronic sinusitis, defective mucociliary transport and bronchial clearance, bronchiectasia, chronic otitis media and incapacitating headaches, related to immotility of ependymal cilia in the walls of cerebral ventricles; other defects associated with IC include cardiovascular, renal and ocular defects, and absence of frontal sinuses Reproduction ♂ are infertile,¹⁄₂ of ♀ are impregnatable, the other¹⁄₂ sterile;¹⁄₂ have Kartagener's triad, ie chronic sinusitis, bronchiectasis and situs inversus totalis, the last of which may be due to an in utero defect with contrary beating cilia. See Cilia.