immature teratoma

immature teratoma

Adults
A teratoma with both mature elements from all 3 germ-cell layers (ectodermal, mesodermal, and endodermal), and immature (embryonic, not foetal) tissues, most commonly of neural origin, consisting of primitive neurotubules, neuroepithelial rosettes, immature glial elements, immature ependyma, primitive muscle.

Prognosis
Relatively good if under age 15; guarded if adult (see table).

Grade, Immature teratoma
I)  ≤ 1 focus/slide contains immature tissue—low-grade.
II)  2–3 foci contains immature tissue—high-grade, adjuvant radiation therapy; survival possible.
III) 4+ foci contains immature tissue—high-grade, adjuvant radiation therapy; prognosis very poor.

Based on any immature tissue on any 1 slide at 40X (low-power field).

Children
Immature teratomas behave differently in children; grading is unnecessary, the only histological predictor of recurrence is the presence of foci of yolk-sac tumour (confirmed by IHC stains for CK, AFP, glypican 3, SALL4); immature neural tissue does not indicate malignancy in immature teratomas of infants as it does in adults.

immature teratoma

Malignant teratoma A teratoma that has mature elements from all 3 germ cell layers–ectodermal, mesodermal, and endodermal, and immature tissues, most commonly of neural origin; the neural tissues in ITs consist of primitive neurotubules, neuroepithelial rosettes, immature glial elements, immature ependyma
References in periodicals archive ?
While more aggressive imaging features such as the presence of an enhancing soft tissue mass invasion to adjacent structures, inhomogenous enhancement, necrosis or hemorrhage are suggestive of malignancy, imaging differentiation between the benign mature and the malignant immature teratoma is not always possible.
0%) had malignant masses (specifically, one Krukenberg tumor, one dysgerminoma, one malignant mixed tumor, one immature teratoma, one mucinous adenocarcinoma, and two primitive neuroectodermal tumors (PNETs)), and one woman (5.
A 16 x 14 cm mass in the right lung was excised by thoracic surgery department, and the pathological diagnosis was immature teratoma.
This description is consistent with immature teratoma with abundant immature neuroepithelial tissues.
A 36-year-old woman presented 6 years after oophorectomy for a right adnexal mass reported on histopathology as an immature teratoma.
Non-puerperal uterine inversion associated with an immature teratoma of the uterus in an adolescent.
reported 126 patients with SCT and the histology showed mature teratoma in 69%, immature teratoma in 20%, and endodermal sinus tumor in 11% of patients (8).
The other tumour, which has a strong resemblance to adult Wilms' tumour are lymphoma, peripheral neuroectodermal tumour, rhabdomyosarcoma, rarely primary renal cell sarcoma and immature teratoma.
Postoperative paraffin pathology found a mixed germ cell tumor (GCT) composed of immature teratoma, dysgerminoma [Figure 1], and yolk sac tumor [Figure 2] in right ovary while a mixed tumor composed of GCT and sex cord stromal tumor (mature teratoma and gonadoblastoma) was identified in left ovary.
Immature teratoma is the most frequent MOGCT74 and the histologic assessment of its degree of immaturity is a highly reliable prognostic factor and therapeutic indicator.
Germ cell tumours were composed of immature teratoma 11%, yalk sac tumour 9%, mixed germ cell tumour 4% and a single case of dysgerminoma with a frequency of 2%.
Histology identified an immature teratoma that was made up of tissue derived from various germ-cell layers and comprised mature glial/neurofibrillary tissue with scattered neurons predominant (figure 2).