imidazoles


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to imidazoles: clotrimazole, Triazoles

imidazoles

A class of antifungal and antibacterial drugs effective against a wide range of bacteria and fungi. The group includes METRONIDAZOLE (Flagyl), MEBENDAZOLE, THIABENDAZOLE (tiabendazole), CLOTRIMAZOLE (Canesten), ketoconazole and miconazole.

imidazoles

group of topical and systemic broad-spectrum anti-fungal agents; used to treat yeast and dermatophyte infections; see clotrimazole; econazole; ketoconazole; miconazole; and Table 1
Table 1: Treatment of fungal infections of skin and nails
Infection siteAgent
Antimycotic agent (for the treatment of dermatophytosis)
SkinTopical allylamine (e.g. 1% terbinafine cream for 7 days)
Topical imidazoles (e.g. 2% miconazole or 1% clotrimazole for 28 days)
Topical 0.25% amorolfine
Topical 1% econazole
Topical griseofulvin spray (400 μg puff daily for 14 days)
Topical 1% sulconazole
Topical tea tree (manuka) oil
Topical undecenoate (20% zinc undecenoate + 5% undecenoic acid)
Topical Whitfield's ointment (6% benzoic acid + 3% salicylic acid)
Other topicals include: weak iodine solution 2.5%; potassium permanganate paint 1%; salicylate acid cream or alcoholic solution 3-5%; benzoic acid (Whitfield's) ointment; sodium polymetaphosphate dusting powder
Systemic terbinafine (250 mg daily for 2 weeks)
Systemic itraconazole (100 mg daily for 15 days)
Systemic griseofulvin (500 mg daily )
NailTopical amorolfine 0.25% lacquer as an adjunct to systemic treatment
Topical borotannic acid complex acid; Phytex paint (1.46% salicylic acid + 4.89% tannic acid + 3.12% boric acid)
Topical 28% tioconazole lacquer
Topical undecenoate lacquer; Monphytol paint (5% methyl undecenoate + 0.7% propyl undecenoate + 3% salicylic acid + 25% methyl salicylate + 5% propyl salicylate + 3% chlorambucil)
Other topicals: strong iodine 10% solution
Systemic terbinafine (250 mg daily for 12-16 weeks)
Systemic itraconazole (400 mg for 1 week in a month, repeated overall 3 or 4 times)
Anticandidal agent (for the treatment of candidiasis)
SkinTopical antimycotic creams (1% clotrimazole; 1% econazole; 2% miconazole)
Topical nystatin (100 000 units ± 1% tolnaftate)
Antipityriasis versicolor agent (for the treatment of pityriasis versicolor)
SkinTopical 2% ketoconazole
Topical 2.5% selenium sulphide
Topical antimycotic agents (1% clotrimazole; 1% econazole; 2% miconazole; 1% sulconazole; 1% terbinafine)
Systemic fluconazole/itraconazole/ketoconazole/miconazole/voriconazole

imidazoles

a group of synthetic antifungal agents; includes clotrimazole, miconazole, econazole and ketoconazole.
References in periodicals archive ?
2006, "Synthesis and pharmacological activity of some 2-substituted 4, 5-diphenyl imidazoles," Indian J.
2007, "Antinociceptive and anti-inflammatory activities and QSAR studies on 2-substituted-4, 5-diphenyl imidazoles," Bioorganic and Medicinal Chemistry, 15, pp.
Compounds with methoxy and hetero furfuryl substituent at the meta position to the phenyl ring at 2nd position and at the 2nd position to the imidazole ring of the compound X2 and Z8 led to considerable increase in the activity.
2009 "Anthelmintic activity of some 2-substituted 4, 5-diphenyl imidazole," Indian Drugs.
The bioactivity of Imidazole derivatives are attributed by the parent basic heterocycle ring.
The interaction of pure Imidazole with mesenchymal stem cell might provide new insights on the toxic potential of Imidazole in creating any stem cell related pathologies.
Hence, in this study, an attempt is made to elucidate the toxicological response of pure Imidazole following direct contact with bone marrow mesenchymal stem cells.
Assessment of cytotoxicity of pure Imidazole using bone marrow mesenchymal stem cells
The cytotoxicity of pure Imidazole in BMSCs were assessed by morphological changes after Imidazole treatment as well as MTT (3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide) assay.
Also offers a wide range of imidazole accelerators, including 2-methylimidazole, 2-ethyl-4-methylimidazole, and 2-phenylimidazole, as well as several developmental types.
Evaluation of the mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivates by the Ames test and the SOS chromotest.