idiotype

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id·i·o·type

(id'ē-ō-tīp),
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones; also found on the T-cell receptor. See: idiotope.
[idio- + G. typos, model]

idiotype

(ĭd′ē-ə-tīp′)
n.
1. A set of one or more antigenic determinants specific to the variable region of an immunoglobulin molecule.
2. A set of immunoglobin molecules that have the same antigen-binding specificity in their variable regions.

idiotype

[id′ē·ətīp′]
Etymology: Gk, idios + typos, mark
the portion of an immunoglobulin molecule that confers the molecule's unique character, most often including its antigen-binding site.

id·i·o·type

(id'ē-ō-tīp)
A determinant that confers on an immunoglobulin molecule an antigenic "individuality" and is frequently a unique attribute of a given antibody in a given animal.
[idio- + G. typos, model]

idiotype

unique part of the variable region of an antibody that can itself act as an antigen for another ANTIBODY. see ANTIIDIOTYPE.

idiotype (iˈ·dē·ō·tīpˑ),

n the region of an immunoglobulin molecule responsible for the unique characteristics of the molecule. In most cases, this includes the antigen-binding location.

id·i·o·type

(id'ē-ō-tīp)
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones.
[idio- + G. typos, model]

idiotype

the antigenic characteristic of the variable region of an antibody. A set of idiotopes. Called also Id.

cross-reacting idiotype (IdX)
one that is present on other immunoglobulins produced in response to the same antigen, permitting a cross reaction. See also cross-reaction.
References in periodicals archive ?
A number of researchers in the field say they were skeptical of the paper's central claim of idiotypic mimicry from the start.
Imanishi-Kari's team analyzed the antibodies produced by the mouse cells, providing the bulk of the scientific evidence for idiotypic mimicry.
Most of the scientists interviewed by SCIENCE NEWS said they were startled by the central claim of idiotypic mimicry when the CELL paper came out in 1986.
Another interesting and controversial idea is the idiotypic network hypothesis proposed by Jerne (1974).
The use of nonspecific blocking agents efficiently protects current immunoassays against interference from isotypic antibodies but probably protects less efficiently against idiotypic antibodies (5).
These multispecific, or polyreactive, antibodies often exhibit properties of autoantibodies, are frequently IgM rheumatoid factor, are more common among neonates, and may be idiotypic antibodies (11,13-15), which is in accord with the idiotypic-antiidiotypic antibody regulatory network theory of Jerne (17).
Fab-Fab, bridging of Fab regions of immunoglobulins as a result of idiotypic antibody binding.
2a] heavy or kappa light chain but rather are allo- or idiotypic epitopes.
If this is true, we also would assume that the HAMAs insensitive to MAK33 are directed against allotypic or idiotypic epitopes (idiotopes) not related to the isotype of the Ig[G.
This is in accordance with other reports that describe an early HAMA response to the isotypic epitopes followed by an increasing specificity for the idiotypic epitopes after repeated infusion of murine antibodies (14,15).
Interference may also result from idiotypic antibody interactions.