idiotype


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Related to idiotype: isotype, allotype

id·i·o·type

(id'ē-ō-tīp),
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones; also found on the T-cell receptor. See: idiotope.
[idio- + G. typos, model]

idiotype

(ĭd′ē-ə-tīp′)
n.
1. A set of one or more antigenic determinants specific to the variable region of an immunoglobulin molecule.
2. A set of immunoglobin molecules that have the same antigen-binding specificity in their variable regions.

idiotype

[id′ē·ətīp′]
Etymology: Gk, idios + typos, mark
the portion of an immunoglobulin molecule that confers the molecule's unique character, most often including its antigen-binding site.

id·i·o·type

(id'ē-ō-tīp)
A determinant that confers on an immunoglobulin molecule an antigenic "individuality" and is frequently a unique attribute of a given antibody in a given animal.
[idio- + G. typos, model]

idiotype

unique part of the variable region of an antibody that can itself act as an antigen for another ANTIBODY. see ANTIIDIOTYPE.

idiotype (iˈ·dē·ō·tīpˑ),

n the region of an immunoglobulin molecule responsible for the unique characteristics of the molecule. In most cases, this includes the antigen-binding location.

id·i·o·type

(id'ē-ō-tīp)
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones.
[idio- + G. typos, model]

idiotype

the antigenic characteristic of the variable region of an antibody. A set of idiotopes. Called also Id.

cross-reacting idiotype (IdX)
one that is present on other immunoglobulins produced in response to the same antigen, permitting a cross reaction. See also cross-reaction.
References in periodicals archive ?
Abisheva NN, Beduleva LV, Menshikov IV, Ivanov VV (2010) Investigation of the mechanisms on idiotype regulation of the immune response in the experimental model of autoimmune hemolytic anemia in mice.
By knowing the landscape of the AMMI parameter space, with the locations of current winners and the regions for potential and even universal new winners, desirable idiotypes can be defined.
When the researchers looked at the antibodies produced by the hybridomas, they found that 28 percent of the hybridomas from spleen cells and 68 percent of those from lymph nodes produced antibodies carrying the distinctive idiotype of the foreign gene.
The idiotype recognizes portions of disease organisms or cancer cells that can be thought of as sticking out from those objects like hands.
Under terms of the agreement, Stellar Biotechnologies supplies Keyhole Limpet Hemocyanin (KLH) which is coupled to the idiotype protein produced in tobacco plants.
Therefore, the interfering antibodies might be idiotypic antibodies that bind to a unique idiotype present on the Elecsys anti-TSH antibodies but not on the Centaur and Architect antibodies.
The finding that the prolactin concentration measured by the VIDAS decreased after treatment with the HBT blocking agent supports the hypothesis that the interfering antibody was an IgM, an idiotypic antibody that binds to a unique idiotype on the VIDAS antibodies.
Presumably this is attributable to different blocking reagents in different assay configurations or possibly to an idiotype specificity of the interfering antibodies (17).
Generally, isotype antibodies may be more common than idiotype antibodies.