idiotype


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Related to idiotype: isotype, allotype

id·i·o·type

(id'ē-ō-tīp),
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones; also found on the T-cell receptor. See: idiotope.
[idio- + G. typos, model]

idiotype

(ĭd′ē-ə-tīp′)
n.
1. A set of one or more antigenic determinants specific to the variable region of an immunoglobulin molecule.
2. A set of immunoglobin molecules that have the same antigen-binding specificity in their variable regions.

idiotype

[id′ē·ətīp′]
Etymology: Gk, idios + typos, mark
the portion of an immunoglobulin molecule that confers the molecule's unique character, most often including its antigen-binding site.

id·i·o·type

(id'ē-ō-tīp)
A determinant that confers on an immunoglobulin molecule an antigenic "individuality" and is frequently a unique attribute of a given antibody in a given animal.
[idio- + G. typos, model]

idiotype

unique part of the variable region of an antibody that can itself act as an antigen for another ANTIBODY. see ANTIIDIOTYPE.

idiotype (iˈ·dē·ō·tīpˑ),

n the region of an immunoglobulin molecule responsible for the unique characteristics of the molecule. In most cases, this includes the antigen-binding location.

id·i·o·type

(id'ē-ō-tīp)
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones.
[idio- + G. typos, model]

idiotype

the antigenic characteristic of the variable region of an antibody. A set of idiotopes. Called also Id.

cross-reacting idiotype (IdX)
one that is present on other immunoglobulins produced in response to the same antigen, permitting a cross reaction. See also cross-reaction.
References in periodicals archive ?
Bullet Bio's lead product, BB-001, is a fully personalized active immunotherapy that uses a unique marker on B-cell lymphoma cells, the idiotype protein, to train a patient's own immune system to target their cancer cells.
When the researchers looked at the antibodies produced by the hybridomas, they found that 28 percent of the hybridomas from spleen cells and 68 percent of those from lymph nodes produced antibodies carrying the distinctive idiotype of the foreign gene.
However, the CELL authors claimed that in most hybridomas, the transferred gene didn't get turned on at all but somehow forced the mouse's own genes to direct production of antibodies with the same idiotype as the foreign gene.
Neelapu states, "BiovaxID induces both antibody and T-cell responses against the idiotype (Id), which is the tumor-specific antigen expressed on B-cell lymphomas such as follicular lymphoma.
Favrille announced results from a new study showing enhanced activity from insect-cell derived idiotype proteins, a key component in the Company's Id/KLH immunotherapy product candidate FavId for B-cell NHL, compared to idiotype proteins produced using mammalian cells.
a biopharmaceutical company developing patient-specific, active immunotherapies for the treatment of cancer, announced results from a new study showing enhanced activity from insect-cell derived idiotype (Id) proteins, a key component in the Company's Id/KLH immunotherapy product candidate FavId(R) for B-cell non-Hodgkin's lymphoma (NHL), compared to Id proteins produced using mammalian cells.
Timmerman, entitled "Enhanced Immunostimulation by a Therapeutic Lymphoma Idiotype Vaccine Produced in Insect Cells Involves Mannose Receptor Targeting to Antigen Presenting Cells," is now available on the Investor Relations section of Favrille's web site at http://www.
OMT's genetic engineering is based on an improved understanding of B cell development and a new approach to inactivation of endogenous antibody expression, which enables OmniRat to make antibodies with human idiotypes as efficiently as wild type rats make normal antibodies.
This test involves separation of EPO idiotypes by isoelectric focussing, immunoblotting, and detection of IgG labeled with streptiverdin-peroxidase.
OmniRat (TM) uses an improved understanding of B cell development and a new approach to inactivation of endogenous antibody expression, which enables them to make antibodies with human idiotypes as efficiently as wild type rats make normal antibodies.
While there have been numerous transgenic mice expressing human antibodies, this is the first genetic engineering project that resulted in an animal that makes antibodies with fully human idiotypes as well as wild type animals make their own antibodies.
Roland Buelow, Founder and CEO of OMT, said: "OmniRat makes antibodies with fully human idiotypes as well as normal rats make normal rat antibodies.