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idiotype

   Also found in: Dictionary/thesaurus, Wikipedia 0.06 sec.
id·i·o·type (d--tp)
n.
A determinant that confers on an immunoglobulin molecule an antigenic individuality that is analogous to the individuality of the molecule's antibody activity.

idiotype
[id′ē·ətīp′]
Etymology: Gk, idios + typos, mark
the portion of an immunoglobulin molecule that confers the molecule's unique character, most often including its antigen-binding site.

idiotype (iˈ·dē·ō·tīpˑ),
n the region of an immunoglobulin molecule responsible for the unique characteristics of the molecule. In most cases, this includes the antigen-binding location.

idiotype
the antigenic characteristic of the variable region of an antibody. A set of idiotopes. Called also Id.

cross-reacting idiotype (IdX)
one that is present on other immunoglobulins produced in response to the same antigen, permitting a cross reaction. See also cross-reaction.


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When the researchers looked at the antibodies produced by the hybridomas, they found that 28 percent of the hybridomas from spleen cells and 68 percent of those from lymph nodes produced antibodies carrying the distinctive idiotype of the foreign gene.
In an accompanying editorial, Idiotype vaccination in follicular lymphoma: knocking on the doorway to a cure, Dr.
justifications have been provided that autologous tumor-derived immunoglobulin idiotype coupled to keyhole limpet hemocyanin may be of significant benefit to those affected by the condition.
 
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