idiopathic sideroblastic anemia

Acquired refractory sideroblastic anemia, idiopathic acquired sideroblastic anemia Hematology A pluripotent stem cell defect characterized by ineffective erythropoiesis with a slight ↓ in RBC survival, mild maturational impairment of all hematopoietic cell lines, coupled with defective iron metabolism and iron accumulation; ISA affects older Pts, often related to radio- or chemotherapy, 10-30% of whom later develop acute non-lymphocytic leukemia Clinical Pallor, fatigue, weakness, dyspnea and palpitations on exertion Lab 'Dimorphic' anemia with hypochromic-microcytic and macrocytic features; 40% of erythroblasts are ring sideroblasts, anisocytosis, basophilic stippling, reticulocytes with impaired heme synthesis, ↓ delta ALA synthetase and protease activity Treatment Pyridoxine is often administered, usually without therapeutic response Prognosis ISA
is usually characterized by chronic stable anemia, and less commonly by evolution to leukemia, or to BM failure. Cf Refractory anemia with excess blasts.

Mentioned in	?		Medical browser	?		Full browser	?
anemia dysmyelopoietic syndrome macrocytic Normocytic PISA RARS			idiopathic hemosiderosis idiopathic hydrocephalus idiopathic hypercalcemia of infants idiopathic hypercalciuria idiopathic hypertrophic cardiomyopathy idiopathic hypertrophic osteoarthropathy idiopathic hypertrophic subaortic stenosis idiopathic hypoventilation Idiopathic Infiltrative Lung Diseases idiopathic megacolon idiopathic midline destructive disease idiopathic multiple pigmented hemorrhagic sarcoma idiopathic necrotizing crescentic glomerulonephritis idiopathic nephrotic syndrome idiopathic neuralgia idiopathic pericarditis idiopathic postpartum renal failure idiopathic pulmonary fibrosis idiopathic pulmonary hemorrhage idiopathic pulmonary hemosiderosis idiopathic pulmonary hypertension idiopathic reactive hypoglycemia idiopathic respiratory distress syndrome idiopathic retroperitoneal fibrosis idiopathic scoliosis idiopathic sideroblastic anemia idiopathic steatorrhea idiopathic tetanus idiopathic thrombocytopenic purpura idiopathic ventricular tachycardia idiopathy idioretinal Idiospermum australiense idiosyncrasy idiosyncratic idiosyncratic drug effect idiot idiot fruit idiot savant idiotope idiotrophic idiotype idioventricular idioventricular rhythm IDL IDM idopsin idoxifene idoxuridine idoxuridine-IDU IDR			Idiopathic pulmonary fibrosis and usual interstitial pneumonia idiopathic pulmonary hemisiderosis idiopathic pulmonary hemorrhage idiopathic pulmonary hemosiderosis idiopathic pulmonary hemosiderosis idiopathic pulmonary hypertension idiopathic reactive hypoglycemia Idiopathic Recurrent Palmoplantar Hidradenitis idiopathic resorption idiopathic resorption idiopathic resorption idiopathic respiratory distress of newborn idiopathic respiratory distress of newborn idiopathic respiratory distress of newborn idiopathic respiratory distress of newborn idiopathic respiratory distress syndrome Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis idiopathic retroperitoneal fibrosis Idiopathic Right Ventricular Tachycardia Idiopathic Sclerosing Encapsulating Peritonitis Idiopathic Sclerosing Peritonitis Idiopathic scoliosis Idiopathic scoliosis Idiopathic scoliosis Idiopathic scoliosis idiopathic seborrhea, primary seborrhea idiopathic seborrhea, primary seborrhea idiopathic seborrhea, primary seborrhea Idiopathic Segmental Infarction of the Greater Omentum Idiopathic Sensory Neuropathy idiopathic sideroblastic anemia Idiopathic Spinal Cord Herniation idiopathic steatorrhea idiopathic steatorrhea idiopathic sterile g's idiopathic sterile g's idiopathic sterile g's Idiopathic Subluxation of the Radial Head Idiopathic Sudden Progressive Deafness Idiopathic Sudden Sensorineural Hearing Loss Idiopathic Sudden Sensorineural Hearing Loss Syndrome idiopathic tetanus idiopathic tetanus idiopathic tetanus Idiopathic thrombocytopenia Idiopathic thrombocytopenia Idiopathic thrombocytopenia Idiopathic thrombocytopenia purpura Idiopathic thrombocytopenia purpura Idiopathic thrombocytopenia purpura idiopathic thrombocytopenic purpura idiopathic thrombocytopenic purpura idiopathic thrombocytopenic purpura idiopathic thrombocytopenic purpura Idiopathic Thrombosis idiopathic ulcerative colitis Idiopathic Ventricular Fibrillation Idiopathic Ventricular Fibrillation idiopathic ventricular tachycardia Idiopathic Verapamil-Responsive Left Ventricular Tachycardia Idiopathic vitamin K deficiency in infancy