During 1993-1996, investigation of cases of acute idiopathic pulmonary hemorrhage (AIPH) among infants in Cleveland, Ohio (i), suggested an association between AIPH and being male, exposure to molds (notably Stachybotrys chartarum), exposure to environmental tobacco smoke, and lack of breastfeeding.
Summary of epidemiologic, laboratory, and environmental findings from four reported cases of acute idiopathic pulmonary hemorrhage (AIPH) among infants--Massachusetts, December 2002-June 2003 Epidemiologic/ Environmental findings Infant A Epidemiologic Date of illness onset December 2002 Age at illness onset 45 days Race/Ethnicity White, non-Hispanic Sex Male Maternal perinatal and/or infant Yes/No antibiotic use Upper respiratory infection Yes symptoms <2 weeks of AIPH Reported family history von Willebrand disease of bleeding disorders Infant history of susceptibility No to bruising Possible history of unintentional No asphyxiation or trauma Abnormal hospital hematology Hemoglobin: reduced, laboratory findings 8.
Availability of case definition for acute idiopathic pulmonary hemorrhage among infants.
Questions have been raised whether stachhybotrys chartarum can cause acute idiopathic pulmonary hemorrhage
In response to CDC recommendations published in March 2000 (1), CDC has established procedures for the surveillance of acute idiopathic pulmonary hemorrhage in infants (AIPHI) and for conducting investigations and special studies.
The full proposed case definition and classification scheme "Case Definition for Acute Idiopathic Pulmonary Hemorrhage in Infants" is available at http://www.
In December 1994 and January 1997, articles in MMWR described a cluster of 10[*] infants from Cleveland, Ohio, with acute idiopathic pulmonary hemorrhage, also referred to as pulmonary hemosiderosis [1,2].
Environmental risk factors associated with pediatric idiopathic pulmonary hemorrhage and hemosiderosis in a Cleveland community.
Reports of Members of the CDC External Expert Panel on Acute Idiopathic Pulmonary Hemorrhage in Infants: a synthesis.