cutaneous (redirected from idiopathic cutaneous and renal glomerular disease)

cutaneous /cu·ta·ne·ous/ (ku-ta´ne-us) pertaining to the skin.

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cu·ta·ne·ous (ky-tn-s)

adj.

Of, relating to, or affecting the skin.

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Cutaneous

Pertaining to the skin.

Mentioned in: Anthrax, Cutaneous T-Cell Lymphoma, Diphtheria

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cutaneous

[kyo̅o̅tā′nē·əs]

Etymology: L, cutis, skin

pertaining to the skin.

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cutaneous (kūtā´nēus),

adj relating to the skin. Tests of cutaneous hypersensitivity may be indicators of malnutrition and are useful in determining a patient's readiness for surgery.

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cutaneous

pertaining to the skin. See also under headings of individual diseases, e.g. cutaneous actinobacillosis.

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idiopathic cutaneous and renal glomerular disease

a disease affecting racing Greyhounds caused by a Shigella-like toxin produced by Escherichia coli H157:07, found in uncooked meat. There is a severe vasculitis with cutaneous necrosis, renal failure and death. Called also Alabama rot, Greenetrack disease.

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anthrax

Greek, anthrax, a burning coal, charbon, milzbrand Infectious disease An often fatal bacterial infection which occurs when Bacillus anthracis endospores, primarily of grazing herbivore–cattle, sheep, horses, mules–origin enter via skin abrasions, inhalation, or orally Pathogenesis Anthrax endospores germinate within macrophages, become vegetative bacteria, multiply within the lymphatics, enter the bloodstream and cause massive septicemia Clinical URI-like symptoms, followed by high fever, vomiting, joint pain, SOB, internal and external hemorrhage, hypotension, meningitis, pulmonary edema, shock sudden death; intestinal anthrax is caused by ingestion of contaminated meat; cutaneous anthrax is rare Diagnosis ELISA for capsule antigens–95+% senstivity, for protective antigen–72% sensitivity; detection of exotoxins in blood is unreliable Prevention Prophylaxis–6 wks with doxycycline or ciprofloxacin; vaccination, with anthrax vaccine absorbed; decontamination with aerosolized formalin Management Penicillin, doxycycline; if allergic to penicillin, chloramaphenicol, erythromycin, tetracycline, ciprofloxacin See Bacillus anthracis, Cutaneous anthrax, Industrial anthrax, Inhalation anthrax

Anthrax, clinical forms

Pulmonary

Almost universally fatal–due to inhalation of anthrax spores which germinate and produce toxins resulting in pleural effusions, hemorrhage, cyanosis, SOB, stridor, shock, death

Inhalation

Anthrax pneumonia, inhalational anthrax, pulmonary anthrax An almost universally fatal form due to inhalation of 1 to 2 µm pathogenic endospores which are deposited in alveoli, engulfed by macrophages and germinate en route to the mediastinal and peribronchial lymph nodes, produce toxins Clinical Mediastinal widening, pleural effusions, fever, nonproductive cough, myalgia, malaise, hemorrhage, cyanosis, SOB, stridor, shock, death, often accompanied by mesenteric lymphadenitis, diffuse abdominal pain, fever

Cutaneous

Once common among handlers of infected animals, eg farmers, woolsorters, tanners, brushmakers and carpetmakers in an era when brushes were from animals Clinical Carbuncle–a cluster of boils, that later ulcerates, resulting in a hard black center surrounded by bright red inflammation; rare cases which become systemic are almost 100% fatal

Gastrointestinal

After ingesting contaminated meat–2 to 5 days; once ingested spores germinate, causing ulceration, hemorrhagic and necrotizing gastroenteritis Clinical Fever, diffuse abdominal pain with rebound tenderness, melanic stools, vomit, fluid and electrolyte imbalances, shock; death is due to intestinal perforation or anthrax toxemia

Oropharyngeal

Uncommon, follows ingestion of contaminated meat Clinical Cervical edema, lymphadenopathy–causing dysphagia, respiratory difficulty

Anthrax meningitis

A rare, usually fatal complication of GI or inhalation anthrax with death occurring 1 to 6 days after onset of illness Clinical Meningeal symptoms, nuchal rigidity, fever, fatigue, myalgia, headache, N&V, agitation, seizures, delirium, followed by neurologic degeneration and death

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