For this, different drugs were administered to the rats during the neonatal period: CLI, vehicle, scopolamine (a drug which deprives the animal of REM sleep by blocking colinergic activity) and idazoxan
(a drug which increases adrenergic availability, decreases REM sleep; Velazquez-Moctezuma, Aguilar-Garcia, & Diaz-Ruiz, 1993).
An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan
9 nM), idazoxan
(12 nM), BRL-44408 (15 nM), oxymetazoline (25 nM), yohimbine (63 nM), ARC-239 (76 nM), prazosin (4900 nM) and terazosin (5000 nM) correlated best with affinities previously published for the [[alpha].
2]-adrenergic antagonist idazoxan
on mood, memory and attention in normal volunteers.
The rank-order of affinities was cirazoline [greater than] harmane [greater than] BDF6143[greater than] idazoxan
= tizanidine (affinities of agmatine, efaroxan, moxonidine, norepinephrine, and oxymetazoline were too low to be reliable).
Field immobilization of bighorn sheep with xylazine hydrochloride and antagonism with idazoxan