Injecting animals intraperitoneally with d-galactose to induce acute senility, and then injecting them with [beta] amyloid fragment 1-42 and ibotenic acid into the bilateral hippocampus led to significant learning and memory deficits in the Morris water maze test.
To probe the feasibility and usefulness of the tree shrew as an AD model, we examined the behavior and pathology of animals treated with the combination of d-galactose, [beta] amyloid fragment 1-42 and ibotenic acid.
Discriminable excitotoxic effects of ibotenic acid AMPA, NMDA and quinolinic acid in the rat laterodorsal tegmental nucleus.
Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats.
ingredients found in Amanita mushrooms , ibotenic acid
could not be
GluCls are activated by the glutamate analog, ibotenic acid
, and are inhibited weakly by the ligand-gated chloride channel blocker, picrotoxin (Smith et al.
Two primary compounds, ibotenic acid and muscimol, are known to occur in pharmacologically active levels and are partially, if not entirely, responsible for Amanita muscaria's psychoactive effects.
Ibotenic acid is the most abundant of the principal compounds, and easily degrades into muscimol through the loss of a carboxyl group.
Tenuifolin is shown to improve learning and memory ability of dementia-like rats induced by combined injection of [alpha]-amyloid peptide and ibotenic acid
into the right nucleus basalis magnocellularis.
What does for the unfortunate insects is the ibotenic acid
in the mushroom's cells.
When the monkeys had developed a severe and stable form of the disease, the team injected a neurotoxin called ibotenic acid
directly into the subthalamic nucleus of each animal's brain.