A 58-61, XXXX, hypotriploid chromosome was detected in the cytogenetics report of a 28 years old female patient, known case of B-cell Acute Lymphoblastic Leukaemia.
Keywords: Hypotriploid, Cytogenetics, Leukaemia, Karyotype.
Amongst many cytogenetic abnormalities found in B-cell ALL, we are describing the coincidence of hypotriploid chromosome number in a patient admitted in Jinnah Postgraduate Medical Center in the department of Oncology.
7 There are only few case reports or articles published in Pakistan about a Hypotriploid or Hypertriploid chromosome number in patients with ALL and we think more data should be collected and studied to better understand the pattern and demographics of chromosomal abnormalities in B-cell ALL in Pakistan.
8 And according to a research, these cases of hypotriploid chromosome tend to have better outcome just like our case where the woman achieved complete remission.
Even though hypotriploid number has good prognostic outcome after treatment, some patients do relapse.
Two studies have focused on individual tumor cases and demonstrated presence of abnormal karyotypes with hypotriploid
modal chromosome number and rearrangements affecting chromosomes 1, 8, 12, 21, and 22 (18) and involvement of 2q36-q37 in a subpopulation of cells in another case.