11] EEG studies have shown its ability to regulate faulty sleep patterns,  and another study has shown its ability to stimulate the hypothalamic-pituitary axis
to increase insulin-like growth factor-1 in older female patients.
High FSH levels indicate lack of gonadal function or responsiveness despite a mature hypothalamic-pituitary axis
It does, however, require careful evaluation to determine whether the emerging pubertal features reflect a central process driven by hypothalamic and pituitary factors or whether the problem is peripheral, reflecting abnormally elevated sex steroid hormones but no hypothalamic-pituitary axis aberrations.
If the hypothalamic-pituitary axis is "revved"--pubertal--there will be a massive surge in gonadotropin levels following infusion.
Altered reactivity of the hypothalamic-pituitary axis
in the primary fibromyalgia syndrome.
In contrast, changes in sensitivity of the hypothalamic-pituitary axis
to the feedback actions of gonadal steroids mediate steroid-dependent control of LH release.
Key words: gonadotropin-releasing hormone, hypothalamic-pituitary axis, lead acetate.
The data presented here show that low doses of lead for long periods of time alter the rat hypothalamic-pituitary axis in a manner similar to that previously reported at higher doses for shorter periods of time.
Castrated, lead-treated male rats are able to respond to castration with an increase in LH, indicating an adaptation of the hypothalamic-pituitary axis to the toxic effects of lead (23).
This pattern may be due to the mode of action of Androxal(TM), which appears to be mediated through effects on the hypothalamic-pituitary axis