hypoprothrombinemia


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hypoprothrombinemia

 [hi″po-pro-throm″bĭ-ne´me-ah]
deficiency of prothrombin in the blood.

hy·po·pro·throm·bin·e·mi·a

(hī'pō-prō-throm'bin-ē'mē-ă),
Abnormally small amounts of prothrombin in the circulating blood.
Synonym(s): prothrombinopenia

hypoprothrombinemia

[hī′pōprōthrom′binē′mē·ə]
Etymology: Gk, hypo + L, pro, before; Gk, thrombos, lump, haima, blood
abnormally reduced plasma prothrombin, characterized by bleeding, poor clot formation, and prolonged prothrombin and partial thromboplastin times. It is usually caused by inadequate synthesis of prothrombin in the liver, vitamin K deficiency, or most often by anticoagulant therapy. Also spelled hypoprothrombinaemia. See also blood clotting.

hy·po·pro·throm·bin·e·mi·a

(hī'pō-prō-throm'bin-ē'mē-ă)
Abnormally small amounts of prothrombin in the circulating blood.
Synonym(s): hypoprothrombinaemia.

hypoprothrombinemia (hī´pōprō-throm´binē´mēə),

n a deficiency of prothrombin in the blood. It may be congenital or associated with vitamin K deficiency, large doses of salicylates, liver disease, or excessive anticoagulant. The normal level ranges from 70% to 120% plasma prothrombin concentration. There is little danger of hemorrhage if the prothrombin concentration is greater than 20% of normal.

hypoprothrombinemia

deficiency of prothrombin in the blood.
References in periodicals archive ?
Otherwise usually extraction should be delayed for at least 10 days after birth because of fear of hemorrhage due to hypoprothrombinemia.
Isolated case reports or small series published in the literature are associated with tumors of the adrenal gland and kidney, hypoprothrombinemia associated with cumarin overdose and alcoholic cirrhosis, polycythemia vera, anticoagulant therapy, hemodialysis, retroperitoneal aneurysmal rupture of any blood vessel, and unknown sources.
54) Cephalosporins with the NMTT side chain have also been associated with hypoprothrombinemia and bleeding, a point that should be considered in patients receiving anticoagulants.
The following report illustrates a case of trimethoprim/sulfamethoxazole-induced hypoprothrombinemia in a patient receiving ongoing warfarin therapy for atrial fibrillation and aortic valve replacement.
He subsequently experienced significant hypoprothrombinemia with associated bruising following the concomitant use of TMP/SMX therapy for sinusitis.
4) Several case reports and letters have been published documenting hypoprothrombinemia induced by the concomitant use of warfarin and TMP/SMX,(2)(3)(5)(6)(7)(8)(9) although most predate 1980.
Differential Diagnosis of Menorrhagia in an Adolescent Anatomic abnormality Genital neoplasm (sarcoma botryoides) Genital trauma or laceration Severe vaginitis (especially streptococcal) Foreign body Prolapsed urethra Bleeding abnormality Platelets Platelet dysfunction Thrombocytopenia Clotting disorder Hemophilia A von Willebrand's disease Afibrinogenemia Hypoprothrombinemia Dysfibrinogenemia Induced disorder Ingestion of antiplatelet drugs (aspirin) Hormonal abnormality Anovulatory bleeding Pregnancy complication Threatened abortion