hy·po·pro·throm·bi·ne·mi·a (h  p -pr-thr mb -n  m-)n. Abnormally low levels of prothrombin in the blood. |
hypoprothrombinemia
[hī′pōprōthrom′binē′mē·ə]
Etymology: Gk, hypo + L, pro, before; Gk, thrombos, lump, haima, blood
an abnormal reduction in the amount of prothrombin (factor II) in the circulating blood, characterized by poor clot formation, longer bleeding time, and possible hemorrhage. The condition is usually produced by inadequate synthesis of prothrombin in the liver, most often the result of a deficiency of vitamin K caused by severe liver disease or by anticoagulant therapy with the drug dicumarol. Also spelled hypoprothrombinaemia. See also blood clotting.
hypoprothrombinemia (hī´pōprō-throm´binē´mē
),n a deficiency of prothrombin in the blood. It may be congenital or associated with vitamin K deficiency, large doses of salicylates, liver disease, or excessive anticoagulant. The normal level ranges from 70% to 120% plasma prothrombin concentration. There is little danger of hemorrhage if the prothrombin concentration is greater than 20% of normal.
hypoprothrombinemia
deficiency of prothrombin in the blood.
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