However, in patients with a BMI of greater than 28 and probable OSA, no difference in the number of respiratory events (obstructive apnoeas, hypopnoeas
or central apnoeas) was found between those given IV-PCA morphine compared with those given an 'opioid-sparing' analgesic regimen (IV-PCA tramadol, parecoxib and 'rescue-only' morphine), but there was a correlation between more than 15 respiratory events/hour and central apnoeas with total morphine dose (67).
The average number of episodes of apnoea and hypopnoea
per hour of sleep, the apnoea hypopnoea
index (AHI) was calculated.
today announced that it has received marketing approval from the Medicines Control Agency (MCA) in the United Kingdom to expand the label of Provigil(R) (modafinil) to treat excessive daytime sleepiness in patients with obstructive sleep apnoea/ hypopnoea
BMI was predictive of the rate of obstructive apnoea and hypopnoea
Based on the definition of at least five apnoeas or hypopnoeas
per hour of sleep accompanied by EDS3, the prevalence of OSA is 4 per cent in men and 2 per cent in women between ages 30 and 60.
Epidemiologic studies suggest a high prevalence of both obstructive and central sleep apnoeas, in the elderly (1-6,8-11), with a significant association between age and apnoea-hypopnoea
index (AHI, number of apnoeas and hypopnoeas
per hour of sleep).
is defined as a reduction in airflow (30-50%) that is followed by an arousal from sleep or a decrease in oxyhaemoglobin saturation (3-4%) (5,6).
The diagnosis of OSA is confirmed when a person has an apnoea-hypopnoea
index (AHI; number of apnoeas and hypopnoeas
per hour of sleep) > 5 events/h associated with symptoms of excessive daytime sleepiness (1).
They can be said to have upper airways resistance syndrome (UARS) if there are indications that resistance is high at the time of arousal, even though there is not enough reduction in ventilation or oxygen saturation to satisfy definitions of hypopnoea
Patients with upper airway resistance syndrome (UARS), an entity characterized by flow-limited breathing that results in the disruption of sleep, typically have Pcrit levels between snoring and hypopnoea
The treatment goal should be to normalize the apnoea hypopnoea
index (AHI), but normalizing all levels of AHI in all subsets of patients may not result in improved health outcomes.
The reported success rate of these procedures ranges from 75-100 per cent and long-term improvements in apnoea hypopnoea
index (AHI) and quality of life are seen in about 90 per cent of those who have had MMA (49).