The exact pathogenesis of progressive macular hypomelanosis is unknown; however, recent studies suggest hypopigmentation results from decreased melanin formation and altered melanosome distribution in response to Propionibacterium.
Progressive macular hypomelanosis (PMH) is an idiopathic skin disorder characterized by hypopigmented macules predominantly located on the trunk without scales or any history of skin problems, more common in tropical and subtropical regions.
Several differentials need to be ruled out once PMH is considered including pityriasis alba, post-inflammatory hypopigmentation, idiopathic guttate hypomelanosis and hypopigmented mycosis fungoides.
Progressive macular hypomelanosis of the trunk: primary acquired hypopigmentation.
Progressive and confluent hypomelanosis of the melanodermic metis.
Progressive macular hypomelanosis in Singapore: a clinico-pathological study.
Primary meningeal rhabdomyosarcoma in a child with hypomelanosis of Ito.
Hypomelanosis of Ito: a description, not a diagnosis.
Hypomelanosis of Ito: no entity, but a cutaneous sign of mosaicism.
Hypomelanosis of Ito: a study of 76 infantile cases.
Familial hypomelanosis of Ito: implications for genetic counselling.
Hypomelanosis of Ito and X;autosome translocations: a unifying hypothesis.