Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA Adverse Event Term Placebo 20 to 60 mg/day 80 to 120 mg/day (N=168) (N=164) (N=167) (%) (%) (%) All EPS events 5 12 20 All EPS events, 2 5 9 excluding Akathisia/ Restlessness Akathisia 2 8 11 Dystonia* 0 0 2 Parkinsonism** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer *Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus **Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia
, muscle rigidity, parkinsonism, psychomotor retardation, and tremor
3,4) Echocardiography typically demonstrates multichamber enlargement associated with global hypokinesia
and decreased left ventricular fractional shortening.
Functional abnormalities can be detected on the bright blood cine sequences, and include global or regional hypokinesia
resulting in reduced ejection fraction (EF) as well as increased RV volumes.
Similar to our case, hyperkinetic movements such as tremor and dystonia, as well as disorders of gait and speech are most common, whereas hypokinesia
such as psychogenic parkinsonism is rare.
, characterised by slowness of movement, is one of the main movement disorders that affects Parkinson's patients and can have a major impact on quality of life.
Festination and marked hypokinesia
along with freezing and postural instability lead to frequent falls.
Trans-thoracic echocardiography showed a sub-normal left ventricular ejection fraction (LVEF) of 58% with no left ventricular dilation and discrete segmental hypokinesia
of the lateral wall.
A person with premotor neglect, frequently termed directional hypokinesia
, can move unaffected limbs ably in ipsilateral space but has difficulty directing the limbs into contralesional space.
He suffers from Parkinson's syndrome, a neurological disorder characterized by tremor, hypokinesia
, rigidity and postural instability.
Neurologic examinations were performed daily, and neonatal neurologic conditions were classified as described by Prechtl (22), with each infant assigned to one of three diagnostic groups: normal, abnormal (when one or more of the following neurologic syndromes were present: hyper- or hypokinesia
, hyper- or hypotonia, hemisyndrome, apathy syndrome, hyperexcitability syndrome), or suspect (if only isolated symptoms were present but no defined syndrome was evident).
Other common side effects include diarrhea, hyperkinesias, urine discoloration, hypokinesia
, abdominal pain, dizziness, constipation, fatigue, pain and hallucinations.
Movement disorders common to HD and PD include hypokinesia
, akinesia and dyskinesia.